LONG^®R3IGF-I - An analog of IGF-I

Handling Recommendations

The key factor for flexibility and efficiency

Improving productivity, reducing complexity and mitigating risk is the goal of every Process Development Scientist. For over 20 years, LONG®R3IGF-I (LONG R3) has been a proven cGMP cell culture growth factor used by industry leading biotech companies for commercial biologic processes. 200 times more potent than insulin, available as a lyophilized powder or an easy to use liquid – no other growth factor provides the potency, safety or flexibility for streamlined process development and manufacturing peace of mind.

Key benefits - LONG®R3IGF-I

• Increased cell density, higher viability and extended culture duration
• 200 times more potent than Insulin and 3 times more stable in cell culture
• Available as lyophilized powder or ready-to-use liquid formulation
• cGMP and Animal-free manufacturing process for consistency and regulatory acceptance
• Security supply backed by comprehensive supply chain risk management.

Add it your way - user-friendly formulations for greater flexibility
LONG R3 is the only growth factor available as both a lyophilized powder and an easy to use liquid, both stable at 2-8°C. The liquid formulation is ready to use, there is no need to thaw or reconstitute, just open and dilute directly into cell culture media for streamlined supplementation in small or large-scale cell culture processes. LONG R3 can also be milled into cell culture media for additional flexibility and convenience.

LONG R3 has been used in the production of marketed biologics for over 20 years. Currently there are several FDA, EMEA and the Japanese MHW approved therapeutics on market that use LONG R3, with many more in late-phase clinical trials. Dedicated Product Specialist support is available to guide you through your evaluation and on-going use of LONG R3.

Save money and time by simplifying inventory and supply chain management
LONG R3 is the most stable growth factor on the market. Shipped at ambient conditions and stored at 2-8°C, LONG R3 avoids costly cold-chain shipping and storage requirements. In addition, LONG R3 is 200 times more potent than insulin, requiring less product and a smaller supply chain footprint. ICH Q7 compliant stability trials have confirmed a 5 year shelf life for lyophilized and 3 years (on-going) for the liquid product, allowing customers to purchase large batch sizes and decrease QC costs.

Reduce process complexity through increased potency and stability
LONG R3 is 200 times more potent than insulin and up to 3 times more stable in cell culture for longer efficacy. Easy cell culture addition with reduced feeding, simplifies process complexity whilst maintaining optimal performance.

Specificity is the key to increased productivity
Unlike insulin, LONG R3 specifically targets and activates the type I IGF Receptor (IGF-IR) resulting in greater activation of downstream signaling cascades responsible for proliferation and inhibiting apoptosis. Greater activation of these key pathways results in increased cell density, higher viability and extended cell culture productivity.

Plug and play with multi cell type compatibility
LONG R3 is compatible with multiple cell types including CHO clones, HEK 293, Vero, PerC6, MDCK and fibroblasts. Any mammalian cell type that responds to insulin in cell culture has the potential to respond to LONG R3.

cGMP and animal-free, with quality and regulatory support straight from the source
LONG R3 is manufactured by Repligen to cGMP following ICH Q7 guidelines ensuring product quality and consistency. In addition, no animal derived substances are used in the production of LONG R3 or in the manufacture of the raw materials used in LONG R3 manufacture. SAFC and Repligen partner to provide specialized support to assist customer’s quality, regulatory and audit requirements.

Supply you can count on backed by a comprehensive risk management strategy
LONG R3 has one of the most comprehensive risk mitigation strategies for any cell culture raw material. Repligen manages a global inventory safety stock of over 2 years forecasted demand. This inventory, together with Repligen's multi site cGMP manufacturing capability, ensures an uninterrupted supply to customers.

Application areas - LONG®R3IGF-I

• Industrial mammalian cell culture
• Stem and therapeutic cell culture.

 For pricing and ordering information contact us at bioprocessing@repligen.com