OPUS | Pre-Packed Disposable Columns Homepage

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Any ResinAny ApplicationAny Size

Repligen’s pre-packed disposable column technology enables user specified inputs tailored to specific applications. This means end-users are easily able to replace self-packed glass columns with OPUS pre-packed columns for disposable manufacturing processes.

User specified inputs include:

  • Bed heights between 5 – 30 cm*
  • Chromatography resins from any vendor
  • Application specific qualification criteria

Combined with the largest range of internal diameters available on the market, OPUS is the only pre-packed column platform which can accommodate the chromatography needs of a disposable manufacturing facility.

OPUS Columns for GMP manufacturing applications

OPUS is configurable for any resin, any application, and any industry standard size. New robust, rugged and reproducible design for limited use or campaign use applications.

Column diameters with bed
heights ranging from 5 – 30 cm

  • 10 cm
  • 14 cm
  • 20 cm
  • 25 cm
  • 30 cm
  • 45 cm

OPUS columns for development or bench scale applications

  • 1.2 cm
  • 2.5 cm
  • 5 cm
  • 8 cm

Any Resin

To advance disposable chromatography in the bioprocessing industry, a standard platform is required which can accommodate the wide variety of commercially available resins used in today’s manufacturing processes. OPUS Columns offer unparalleled flexibility in a pre-packed disposable column by accommodating any commercially available resin.

Examples of Common Resins Packed

Any Application

To advance disposable chromatography in the bioprocessing industry, a standard platform is required which can accommodate a wide variety of applications. OPUS Columns offer unparalleled flexibility in a pre-packed disposable format by accommodating any chromatography application.

Examples of Suitable Applications

  • Purification of antibodies, recombinant proteins, and vaccines
  • Virus titre reduction validation
  • Process development
  • Capture and polishing steps

Any Size

Having the right column size is critical to designing an efficient process. OPUS Pre-Packed Disposable columns are available in a range of industry standard diameters, and can be packed in any bed height from 5-30cm.

  • Development or bench scale applications: Standard Column IDs
    • 1.2 cm, 2.5 cm, 5 cm, 8 cm
    • Available Bed Heights
      • 1.2 IDs: 5- 25 cm
      • 2.5, 5 IDs: 5 – 20 cm
      • 8 cm IDs: 5 – 30 cm
  • GMP manufacturing scale applications: Standard Column IDs
    • 10 cm, 14 cm, 20 cm, 25 cm, 30 cm, 45 cm, 60 cm (please inquire)
    • Specify any bed height between 5-30 cm

Sepharose®, MabSelect SuRe™, Mabselect™, Capto™, and Sephacryl™ are registered trademarks of GEHC
Poros®, and MabCapture™ A are registered trademarks of Life Technologies
Ceramic HyperD®, and Ultrogel®, are registered trademarks of Pall Corp
Fractogel® is a registered trademark of Merck Chemicals International
Toyopearl® is a registered trademark of Tosoh Bioscience
Prosep® is a registered trademark of EMD Millipore