Repligen partners with gene therapy developers and manufacturers, providing technology-ready breakthroughs and high impact solutions for plasmid DNA, AAV and Lentivirus viral vector manufacturing.
Novel High Flux Single-use Filtration for Fed-Batch Clarification
TFDF™ (Tangential Flow Depth Filtration) technology unites the benefits of tangential flow (TF) and depth filtration (DF) in a closed and single-use solution that enables 1000 LMH.
KROSFLO® TFDF™ Systems
OPUS® 80R is the first and only pre-packed column enabling purification of over 10 kilograms of protein in a single cycle.
OPUS® Pre-packed Chromatography Columns offer unparalleled flexibility in media choice, application and size. Applying the most advanced pre-packed chromatography column technology available today, OPUS® columns are ready-to-use alternatives to traditional self-packed columns.
A proven turnkey benchtop system for lab-scale process development, the KrosFlo® KR2i Tangential Flow Filtration (TFF) System is fully integrated and easy to use with walkaway automation.
High Productivity Harvest (HPH) is a novel application developed by Repligen that enables you to harvest a fed-batch bioreactor in a fully sterile manner, while eliminating both centrifugation and depth filtration operations typically used for harvest/clarification. A single stage, closed process using the XCell ATF® device, the HPH application provides:
Higher yields compared to traditional harvest technologies
Up to a two-fold increase in protein production
A 0.2µm clarified harvest ready for either batch or continuous chromatography