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Dynamic Dialysis

Dynamic dialysis is an exciting new technology that utilizes fluid dynamics to increase purification efficiency and improve large buffer handling, ideal for the production of fragile proteins, viscous fluids and polymer gels, such as hyaluronic acid. These closed, high-efficiency systems offer high concentration gradient dialysis without manual buffer changes and in-process sample handling.

Lab-scale dynamic Dialysis

To dialyze small 8- 30 ml volumes of delicate samples, dynamic dialysis is achieved by mounting the Spectra/Por® Tube-A-Lyzer onto the support rack of the KrosFlo® Research I Pump System, The system can be operated as a single unit or in parallel when multiple units are combined using a coupling bracket into a multi-unit device. 

Lab-scale dynamic dialysis

Process-scale Dynamic Dialysis

At process-scale, dynamic dialysis is used for the purification of macromolecules, proteins, nanoparticles, biomolecules, polymers (polypeptides, polysacharide, oligos), virus for vaccine and delicate/shear sensitive species. It is also ideal for the purification of viscous fluids and hydrogels (hyaluronic acid – HA) that cannot be filtered. 

Process-scale dynamic Dialysis

dialysis Membranes

Dialysis membranes from Repligen include biotech-grade, standard-grade and custom membranes that can be used in both lab-scale and process-scale operations.

Dialysis Membranes