Explosive growth in biologics is driving increased investments in manufacturing facilities that incorporate transformative technologies and continuous processing, with a focus on flexibility.

CONTINUOUS PROCESSING

XCell™ ATF Cell Retention System

Perfusion, or upstream continuous processing, has been used since the 1980s. High cell density perfusion, or XCell™ ATF perfusion, delivers higher cell concentration and cell viability.

perfusion

XCell™ ATF System

N-1 perfusion refers to the use of an XCell™ ATF device to achieve high cell density in the seed train step before the production bioreactor (N), achieving a more rapid and robust process while maintaining an existing Fed-batch based production scheme. 

N-1 perfusion

PROCESS INTENSIFICATION

High density (HD) cell banking is seed train optimization involving larger volume frozen seed banks, eliminating seed steps from vial and enabling banking of larger volumes up to 1 liter.

high density cell banking

Cell culture growth factors play a critical role in media optimization, contributing to long-term growth and rapid proliferation of cell lines in serum-free media formulations.

Media Optimization - growth factors

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