Founded in 1981 by two pioneering scientists, Repligen is a leader today in bioprocessing filtration technologies, pre-packed chromatography columns and Protein A ligand manufacturing.


Repligen was founded in 1981 by two distinguished scientists who pioneered breakthrough advances in science and technology.

ARich.jpgAlexander Rich was co-Chair of the Repligen Board of Directors until 2014.  He was a Professor at the Massachusetts Institute of Technology since 1958.  Considered a founding father of the field of molecular biology, he received the National Medal of Science in 1995.  He passed away on April 27, 2015 at 90 years old.



Paul_Schimmel_May_2010.jpgPaul Schimmel is the Ernest and Jean Hahn Professor at The Skaggs Institute for Chemical Biology at The Scripps Research Institute. He formerly was the John D. and Catherine T. MacArthur Professor of Biochemistry and Biophysics in the Department of Biology at the Massachusetts Institute of Technology.  His principal scientific contributions include the discovery of “The Second Genetic Code" and expansion of the functional genome.




Since it’s founding in 1981, Repligen has been a leading expert in Protein A. Repligen scientists first cloned the gene for Protein A in 1982, and the Company introduced the world’s first recombinant form of the ligand in 1985. For many years, Protein A was sold as a source of non-dilutive revenue to support a number of drug development programs that the Company was pursuing.

In 2010, Repligen acquired disposable chromatography technology from BioFlash, commercializing the product as OPUS® Pre-packed Chromatography Columns, now the leader and expert in column packing technology.

In 2011, Repligen's transformative acquisition of Novozymes Biopharma AB in 2011 (which included additional Protein A ligands and growth factor products) became the basis of its portfolio of cell culture supplements which quickly doubled its bioprocessing product revenue.

The strategic decision was made in 2012 to divert Repligen’s dual business model to a singularly focused model, based on building its bioprocessing business and taking the opportunity to leverage the strength of the biologics market without being tied to the success or failure of any particular drug.

In 2014, Repligen acquired the assets of Refine Technology, through which it gained the XCell™ ATF System, now a leader in cell culture process intensification.

In April 2016, Repligen acquired Atoll GmBH of Weingarten, Germany to provide customers with the broadest selection of pre-packed chromatography columns from bench-scale to production-scale. These products are now OPUS® PD Pre-packed Columns for process development.

In December 2016,  Repligen acquired TangenX™ Technology Corporation, expanding Repligen's filtration and single-use portfolios, with applications in cell culture, harvest, purification and final fomulation.  

In June 2017, Repligen acquired Spectrum, Inc. to offer the broadest range of hollow fiber and flat sheet filtration technologies for cell culture and purification.

Repligen milestones
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