Repligen has acquired TangenX Technology Corporation of Shrewsbury, MA from Novasep Holding SAS of Lyon, France. The addition of TangenX flagship Sius™ Single-use TFF Cassettes expands Repligen's filtration and single-use portfolios, with applications in key bioprocessing unit operations from upstream cell culture and harvest to downstream purification and final formulation.

  • Sius™ Single-use TFF Cassettes offer significant process efficiency gains in filter cost, labor cost and buffer use.
  • Sius™ Cassettes, combined with leading OPUS® Pre-packed Columns, support key downstream bioprocessing operations from chromatography to final formulation.
  • Sius™ Cassettes expand Repligen’s growing portfolio of innovative single-use offerings, featuring the XCell™ ATF Single-use System for upstream cell culture intensification.


OPUS® Pre-packed Chromatography Columns
Leader of the pack with unparalleled flexibility

  • Production-scale
  • Process development scale

XCell™ ATF Cell Retention Systems
Leader in upstream cell culture process intensification

  • Single-use systems
  • Stainless steel systems

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Sius™ Single-use TFF cassettes

  • First purpose-built single-use  TFF cassettes for ultrafiltration and diafiltration
  • Scalable to 30 m2
  • Compatible with 3rd party hardware

Novaset™ Reusable TFF Cassettes

Cassette hardware

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