OPUS PD Family - all products, no labelsOPUS® Columns for process development, formerly Atoll columns, are used for screening, process validation including viral clearance, scale-up and sample preparation.

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OPUS® PD Columns, formerly Atoll pre-packed columns, are designed specifically for use in process development .

Watch the webinar to see how OPUS® ValiChrom Columns, glass pre-packed columns that are exact scale-down models of corresponding full-scale chromatography columns, are ideal for process validation including viral clearance. It will also demonstrate how OPUS® RoboColumns®, miniaturized columns on a 96-well plate, work with robotic fluid handlers to enable fully automated parallel chromatography and sample preparation.

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OPUS® RoboColumns® are designed to work with robotic fluid handlers for fully automated parallel chromatography.

Up to 96 RoboColumns® (8 column types in parallel) can be individually arranged on a 96-well array plate according to application requirements.  Resin is contained to form a bed between two filter frits and validated with consideration to resin compression requirements, to ensure high efficiency, good asymmetry and robust chromatography performance.

  • Pre-packed with user-specified chromatography resin
  • Consistently packed with correct axial compression
  • Operating linear flow-rate controlled by dispensing speed of the liquid handling workstation
  • Demonstrated scale-up and scale-down due to constant residence time 
  • Large number of samples per time, ability to multiplex

Learn more about OPUS® RoboColumn®

OPUS MiniChrom_inlab2.jpgDesigned for bench-scale resin screening, process development, and sample preparation, OPUS® MiniChrom Columns are pre-packed with user-specified resin and supplied ready to use with any liquid chromatography system.  Flexible column dimension configurations (internal diameters, bed heights, volumes) allow comparative evaluation of process parameters and the construction of customized resin libraries.

  • Pre-packed with user-specified chromatography resin
  • Packed with correct compression factor to deliver high performance from process resins
  • Compatible with all common liquid chromatography systems

Learn more about OPUS® MiniChrom

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OPUS® ValiChrom Columns are high performance glass pre-packed columns designed to be exact scale-down models of corresponding full-scale chromatography columns.  Each column is individually flow-packed according to validated packing protocols with the precision of 1 mm bed height.

OPUS® ValiChrom Columns are ideal for parameter evaluation and optimization, as well as for process validation.

  • Pre-packed with user-specified chromatography resin
  • Flow-packed with correct resin compression factor to simulate performance of process columns
  • Proven reproducibility between packed columns
  • Jacketed glass column with fixed bed height to match process column or user‘s special needs

Learn more about OPUS® ValiChrom

With an internal diameter of 5 cm, the OPUS® 5 Pre-packed Column is ideal for process development assessment of chromatography scale-up prior to clinical or commercial manufacturing.

  • Pre-packed with user-specified chromatography resin
  • Reliable multi-cycle performance
  • Easy cleaning and sanitization
  • Performance maintained after shipping

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Designed for centrifuge parallel handling, the OPUS®  CentriColumn is ideal for high throughput sample preparation.

Up to 96 CentriColumns (8 columns in parallel) can be individually arranged on a 96-well array plate according to application requirements. 

  • Pre-packed with user-specified chromatography resin
  • Compatible with any 96 DIN centrifuge able to accept the 41 mm high CentriColumn array, excluding the base collection plate.

 The OPUS® CentriColumn is available in the following formats:

Internal Diameter   Bed Height         Column Volume 
cm mm   cm   mm   mL  
               
0.5 5.0   0.25 2.5   0.05  
0.5 5.0   0.50 5.0   0.10  
0.5 5.0   1.00 10.0   0.20  

Minimum order is one row of 8 OPUS® CentriColumns with the same resin and column dimensions.

See resin list for OPUS® PD Columns

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Designed for use with positive displacement pipettes, the OPUS® PipetColumn is ideal for lower volume applications and screening, and manual process development prior to working with fully automated OPUS® RoboColumn®.

The OPUS® PipetColumn is operated with positive liquid displacement pipettes (PLD) such as Eppendorf Multipette® Stream or Xstream.  Up to 96 PipetColumns® (8 columns in parallel) can be individually arranged on a 96-well array plate according to application requirements. A Starter Kit is also available, made up of one row of eight PipetColumns.

  • Pre-packed with user-specified chromatography resin
  • Real chromatography mode of operation allows for dynamic vector static chromatography
  • Controlled flow rate by dispensing speed of the used PLD pipette
  • Inexpensive and quick manual process development

The OPUS® PipetColumn is available in the following formats:

Internal Diameter   Bed Height         Column Volume    Resin  
cm mm   cm   mm   mL        
                     
0.5 5.0   0.25 2.5   0.05     AIEX  
0.5 5.0   0.50 5.0   0.10     CIEX  
0.5 5.0   1.00 10.0   0.20     HIC Starter Kit
0.5 5.0   2.25 22.5   0.45     IMAC  
0.5 5.0   2.50 25.0   0.50     Protein A  
0.5 5.0   3.00 30.0   0.60     HA  
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