Reliable, scalable, and cost-effective, TangenX™ solutions enable efficient concentration and diafiltration.

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Repligen TangenX™ products include high-performance membranes and flat sheet cassettes that yield successful results time after time for critical bioprocessing applications. Experienced in the science and art of membrane manufacturing, Repligen is setting the standard in tangential flow filtration solutions for concentration and diafiltration.

TangenX™ flat sheet cassettes and membranes have been in use in the industry since 2006. In 2008, the TangenX™ SIUS™ Cassette was launched as the first purpose-built single-use cassette for tangential flow filtration.  Applications span product development through commercial manufacturing.

TangenX_webinar_May2017. Michael LaBreck, speaker

Tangential flow filtration (TFF), also known as cross-flow filtration, is a type of filtration where majority of the feed flow travels tangentially across the surface of the filter, rather than into the filter. This type of filtration is typically selected for feeds containing a high proportion of small particle size solids.

The feed is passed across the filter membrane at positive pressure relative to the permeate side.  A proportion of the material which is smaller than the membrane pore size passes through the membrane as permeate or filtrate; everything else is retained on the feed side of the membrane as retentate.

A TFF filter can operate continuously at relatively high loads without fouling.

TangenX™ SIUS™ Cassettes are the first purpose-built single-use cassettes for tangential flow filtration (TFF).  They deliver equivalent performance as reusable cassettes but with single-use convenience and at a fraction of the cost. 

  • 80% reduction in filter cost
  • 50% reduction in labor cost
  • 75% reduction in buffer use
  • Scalable from lab to production
  • Interchangeable with TangenX™ PRO Reusable TFF Cassettes

TangenX™ SIUS™ Single-use TFF Cassettes

TangenX™ PRO Reusable Tangential Flow Filtration (TFF) Cassettes are flat sheet cassettes that may be cleaned and re-used multiple times while maintaining reproducible cassette performance. They are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up. 

  • Equivalent performance, interchangeable with TangenX™ SIUS™ Single-use TFF Cassettes
  • Scalable from bench to production scale
  • Up to 30% filter cost reduction compared to other commercial reusable filters

Repligen manufactures  two ultrafiltration membranes: ProStream™ and HyStream™. Both are modified Polyethersulfone (mPES) membranes validated for use in cGMP processes. Both ProStream and HyStream membranes are available in TangenX™ SIUS™ Single-use Cassettes and TangenX™ PRO  Reusable Cassettes.

  • No breakthrough of the ultrafiltration skin, which maximizes selectivity performance
  • Enhanced microporous substructure pore size and even transition, which maximize flux
  • Reduced number of manufacturing steps, which reduces cost and promotes excellent consistency and reliability

TangenX™ membranes

Designed to optimize tangential flow filtration, TangenX™ hardware include:

  • Cassette clamps
  • Cassette holders
  • Filter plate inserts
  • Low Holdup Volume (LHV) turnkey systems
  • Membrane screening systems

TangenX™ hardware

Quality manufacturing

TangenX™ Cassettes are manufactured in a fully validated and documented manufacturing process according to the principles of cGMP.  Each cassette comes with  a Quality Assurance Certificate.

Comprehensive Regulatory Support Files

Each TangenX™ TFF Cassette is supported by a Regulatory Support File (available upon request) that includes:

  • Product information
  • Cassette design
  • Materials of construction
  • Product performance
    • Membrane performance
    • Cassette performance
    • Cassette integrity
    • Cassette pre-flushing study
    • Cassette leachables
    • Robustness study
    • Shelf life study
  • Safety information
  • Documentation system
  • Product Manufacturing
  • Qualification
  • Manufacturing Process Validation
  • Release Testing

Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system.  We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.


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