TangenX PRO and PRO PD- group.pngDesigned to be cleaned and re-used multiple times, TangenX™ PRO and PRO PD Reusable TFF Cassettes are interchangeable with SIUS™ Single-use TFF Cassettes.

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TangenX™ Reusable Tangential Flow Filtration (TFF) Cassettes may be cleaned and re-used multiple times while maintaining reproducible cassette performance. They are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up. 

Validated for GMP use, TangenX™ Reusable TFF Cassettes come in two industry standard format footprints with accompanying holders. They are available using ProStream or HyStream membranes, with choice of pore size and flow-channel configuration.

  • TangenX™ PRO PD for process development
  • TangenX™ PRO for commercial applications

Interchangeable
with SIUS™ Single-use

Scalable
from lab to production

Up to 30% less
than other reusables

Compatible
with all industry holders

Membrane surface areas
0.01 meter²
0.02 meter²
0.10 meter²

Ideal for process development

During process development, scientists aim to select the most promising membrane candidates, while making related decisions regarding feed pressure, TMP and screen geometry.  TangenX™ PRO PD Reusable TFF Cassettes enable process development scientists to select the most promising membrane candidates.

  • Scalable - optimized channel geometry and enhanced device rigidity ensures hydraulic performance is maintained during scale-up
  • Cost savings- up to 30% less cost than other reusable TFF  flat sheet filter cassettes
  • Highly consistent - rigorous QC lot release testing is undertaken for both air integrity and hydrodynamic performanc
  • Compatible with holders from major suppliers (Millipore, Pall, Sartorius)
  • Validated for GMP - Validation Guide and Certificate of Compliance provided to meet regulatory guidelines

To ensure fit with cassette holders from other manufacturers, TangenX™ PRO PD Reusable TFF cassettes are offered with two different notch patterns at the end of the cassette.

TangenX™ PRO PD with standard notch
0.850in (21.59mm) Offset

TangenX notch_850.gif

This format fits the following cassette holders:

  • TangenX™ PRO PD Cassette Holders
  • Pall – Centramate Holder (CM018LV, FS001K10)

TangenX™ PRO PD with offset notch
0.756in (19.21mm) Offset

TangenX notch_756.gif

This format fits the following third part cassette holders:

  • Sartorius – Sartocon Slice Holder (17525—01, 17521–02)
  • GE – Kvick Lab Holder (KLPH01SSU, KLHR0105000SS)
  • Millipore – Pellicon Mini Holder (XX42PMINI)

Membrane Surface Areas
0.5 meter²
1.5 meter²
2.5 meter²

Ideal for scale-up and large-scale commercial applications

When the primary membrane candidate has already been chosen as  a process parameter, the production method needs to be verified and production materials produced for toxicology or pre-clinical trials, and ultimately for large-scale commercial production. TangenX™ PRO Reusable TFF Cassettes provide reliable cassette-to-cassette consistency, ensuring that processes can scale to commercial production levels.

  • Scalable - optimized channel geometry and enhanced device rigidity ensures hydraulic performance is maintained during scale-up
  • Cost savings- up to 30% less cost than other reusable TFF  flat sheet filter cassettes
  • Highly consistent - rigorous QC lot release testing is undertaken for both air integrity and hydrodynamic performanc
  • Compatible with holders from major suppliers (Millipore, Pall, Sartorius)
  • Validated for GMP - Validation Guide and Certificate of Compliance provided to meet regulatory guidelines

Process volume and membrane area determine scale-up from TangenX™ SIUS™ Single-use Cassettes to TangenX™ PRO Reusable TFF Cassettes.

  • Single-use TFF provides the greatest benefit for small to moderate scale operations
  • Reusable TFF is optimal for large production scale operations
  • Contract manufacturing organizations are ideal candidates for single-use TFF

Contact a Repligen representative to simulate cost model for your specific application.

Tangential flow filtration cassettes create turbulence at the membrane's surface and minimize fouling . The result is an increase in performance with a higher permeate flux. The TangenX™ PRO reusable cassettes are offered in three different channel configurations to best suit the application. The channel configuration refers to the type of turbulence promoter incorporated into the feed channel of a cassette. 

H Screen

A fine channel or "H" screen is offered in all TangenX™ PRO cassettes and creates the most turbulence at the membrane's surface ensuing exceptional permeate flux with minimal fouling. This type of turbulence promoter requires the lowest pumping rate and yields the highest cross flow velocity of all three types offered. It also has the highest pressure drop (Delta P) and is easily plugged with small particulates. This type of channel is best suited for dilute feed streams free of particulates with a lower viscosity.

L Screen

A medium channel or L screen is offered in all TangenX™ PRO cassettes and creates a more moderate amount of turbulence at the membrane's surface with minimal fouling. This type of turbulence promoter requires a higher pumping rate than the H screen in order to match the cross flow velocity. When operating at the recommended cross flow rate, it will have a 50% lower pressure drop (Delta P) than the H screen. This type of channel is best suited for clarified feed streams with a moderate to high viscosity. 

 

Suspended Screen

A suspended screen or S channel is offered in all TangenX™ PRO cassettes and consists of a screen suspended over the surface of the membrane using flow spacers. This type of channel creates the least amount of turbulence at the membrane's surface while still minimizing fouling. It also requires the highest pumping rate and can not match the cross flow velocity of the screen channel cassettes. It does however have the ability to pass particulates, such a cells or cell debris through the channel without plugging. This type of channel is best suited for unclarified feed streams or ones with a very high viscosity.

TangenX™ PRO hardware include:

  • PRO PD cassette holders
  • PRO cassette holders
  • PRO Low Holdup Volume (LHV) System

TangenX™ hardware

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