TangenX_SIUS_all.pngTangenX™ SIUS™ Cassettes are the first purpose-built single-use cassettes for tangential flow filtration, delivering unparalleled savings in filter cost, labor cost and buffer use.

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First purpose-built, single-use cassettes for tangential flow filtration (TFF)

TangenX™ SIUS™ Single-use TFF Cassettes deliver the performance of reusable cassettes with single-use convenience at a fraction of the cost. Pre-sanitized and packaged with 0.2M NaOH, the cassettes are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up. 

TFF systems are typically used in a process and then cleaned between uses with a clean in place (CIP) operation. This requires a significant investment in system capacity, raw materials, energy, and time. Validated for GMP use, TangenX™ SIUS™ Single-use TFF Cassettes are a convenient alternative delivered ready to use in two industry standard format footprints. They are available using ProStream or HyStream membranes, with a complete range of pore sizes and flow-channel configurations.

  • TangenX™ SIUS™ PD for process development
  • TangenX™ SIUS™ for commercial applications

80% reduction
in filter cost

50% reduction
in labor cost

75% reduction
in buffer use

Scalable
from lab to production

Membrane surface areas
0.01 meter²
0.02 meter²
0.10 meter²

Ideal for process development

During process development, the aim is to select the most promising membrane candidates while making related decisions regarding feed pressure,  trans-membrane pressure (TMP) and screen geometry. TangenX™ SIUS™ PD Single-use TFF Cassettes save valuable time and resources by eliminating cleaning cycles between experiments. Designed for processing volumes from tens of milliliters to several liters, TangenX™ SIUS™ PD Cassettes enable linear scale processing over a wide range of operating volumes.

  • Unparalleled cost savings- 80% reduction in labor cost, 50% reduction in labor cost, 75% reduction in buffer use
  • Scalable - optimized channel geometry and enhanced device rigidity ensures hydraulic performance is maintained during scale-up
  • Highly consistent - rigorous QC lot release testing is undertaken for both air integrity and hydrodynamic performance
  • Compatible with holders from major suppliers (Millipore, Pall, Sartorius)
  • Validated for GMP - Validation Guide and Certificate of Compliance provided to meet regulatory guidelines

To ensure fit with cassette holders from other manufacturers, TangenX™ SIUS™ PD Single-use TFF cassettes are offered with two different notch patterns at the end of the cassette.

TangenX™ SIUS™ PD with standard notch
0.850in (21.59mm) Offset

TangenX notch_850.gif

This format fits the following cassette clamps and holders:

  • TangenX™ SIUS™ PD Cassette Clamps
  • TangenX™ PRO PD Cassette Holders
  • Pall – Centramate Holder (CM018LV, FS001K10)

TangenX™ SIUS™ PD with offset notch
0.756in (19.21mm) Offset

TangenX notch_756.gif

This format fits the following third part cassette holders:

  • Sartorius – Sartocon Slice Holder (17525—01, 17521–02)
  • GE – Kvick Lab Holder (KLPH01SSU, KLHR0105000SS)
  • Millipore – Pellicon Mini Holder (XX42PMINI)

Membrane surface areas
0.5 meter²
1.5 meter²
2.5 meter²

Ideal for scale-up and large-scale commercial applications

When the primary membrane candidate has already been chosen as  a process parameter, the production method needs to be verified and production materials produced for toxicology or pre-clinical trials, and ultimately for large-scale commercial production. TangenX™ SIUS™ Single-use TFF Cassettes provide reliable cassette-to-cassette consistency, ensuring that processes can scale to commercial production levels.

  • Unparalleled cost savings- 80% reduction in labor cost, 50% reduction in labor cost, 75% reduction in buffer use
  • Scalable - optimized channel geometry and enhanced device rigidity ensures hydraulic performance is maintained during scale-up
  • Highly consistent - rigorous QC lot release testing is undertaken for both air integrity and hydrodynamic performance
  • Compatible with holders from major suppliers (Millipore, Pall, Sartorius)
  • Validated for GMP - Validation Guide and Certificate of Compliance provided to meet regulatory guidelines
 

80% Reduction in Filter Cost

50% Reduction in Labor Cost

75% Reduction in Buffer Use

Process volume and membrane area determine scale-up from TangenX™ SIUS™ PD to SIUS™ Single-use TFF Cassettes.

Tangential flow filtration cassettes create turbulence at the membrane's surface and minimize fouling . The result is an increase in performance with a higher permeate flux. TangenX™ SIUS™ cassettes are offered in three different channel configurations to best suit the application. The channel configuration refers to the type of turbulence promoter incorporated into the feed channel of a cassette. 

L Screen

A medium channel or L screen is offered in all TangenX™ SIUS™ cassette formats. The screen creates turbulence at the membrane's surface ensuing outstanding permeate flux with minimal fouling. This channel configuration requires the lowest pumping rate and yields the highest cross flow velocity. This type of channel is best suited for clarified feed streams over a wide range of viscosities.

EP Screen

A coarser screen channel, the EP channel is offered in all TangenX™ SIUS™ cassettes. The screen geometry of this single-use cassette can process feed streams with a higher viscosity and reduce the overall pressure drop. It is scalable from 100cm2 to 2.5m2, packaged sanitized and compatible with existing cassette holders and FPIs. This type of channel is best suited for processes that use shear sensitive feed streams.

J Channel

A open channel or J channel is offered in all TangenX™ SIUS™ cassettes. A 0.5mm flow spacer separating the membrane creates an open feed flow channel. This type of channel creates the least amount of turbulence while still minimizing fouling. It also requires the highest pumping rate to pass particulates. This type of channel is best suited for unclarified feed streams and is used for processes such as cell harvest operation.

TangenX™ SIUS™ TFF Hardware include:

  • SIUS™ cassette clamps
  • SIUS™ filter plate inserts

TangenX™ Hardware

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