Repligen XCell™ ATF FamilywebH_rev.jpgSimplify and intensify cell culture processes.
The XCell™ ATF System, a cell retention device attached to a bioreactor, delivers high cell density and process intensification.

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Systems

XCell™ ATF Cell Retention System
XCell™ ATF Cell Retention System
XCell™ ATF Cell Retention System

XCell™ ATF 2 System with C24 Controller
non-GMP only

XCell™ ATF 4 System with C24 Controller
non-GMP only

XCell™ ATF 4 System with C410 Controller
GMP and non-GMP possible

XCell™ ATF Cell Retention System
XCell™ ATF 8 System with C410 Controller GMP only
XCell™ ATF Cell Retention System

XCell™ ATF 6 System with C410 Controller
GMP and non-GMP possible

XCell™ ATF 8 System with C410 Controller
GMP only

XCell™ ATF 10 System with C410 Controller
GMP only

Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system.  We focus on the timely delivery of high quality, consistent and robust products, and ensuring business continuity for our customers.

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Below are hollow fiber filter areas, XCell™ ATF pump volumes, and typical bioreactor working volumes paired with each XCell™ ATF System. Actual capacity and vessel size depend upon specific cell culture process conditions.

XCell™ ATF Cell Retention System

The XCell™ ATF System is easy to connect to standard bioreactors, including

  • Glass bioreactors (1L - 20L)
  • Wave type single-use  bioreactor (1L - 1000L) 
  • Stirred tank single-use  bioreactor (2L - 2000L)
  • Stainless steel bioreactors (20L - 2000L)

A complete guide includes the range of standard adaptors and ports that fit all bioreactor equipment.

SEE GUIDE

System components

XCell™ ATF Cell Retention System
 
XCell™ ATF Cell Retention System

C24 Controller
for XCell™ ATF 2, XCell™ ATF 4 Systems

 

C410 Controller
for XCell™ ATF 4, XCell™ ATF 6, XCell™ ATF 8, XCell™ ATF 10 Systems

Consumables

The XCell™ ATF System uses hollow fiber filters to achieve efficient cell retention or separation with low shear. Microfiltration (MF) and ultrafiltration (UF) filters come in five sizes corresponding to the size of the XCell™ ATF System used, and are available in polysulfone or polyethersulfone for reduced protein binding.

There is a variety of hollow fiber filter options that can be selected depending on the specific cell culture process application. Options include:

  • Different membrane types -  polysulfone or polyethersulfone
  • Different microfiltration (MF) membrane pore sizes - 0.1 – 0.65 µ
  • Different ultrafiltration (UF) membrane molecular weight cut offs -  10 Kda – 750 Kda
  • Different surface areas

The Repligen Field Applications team can help select the right hollow fiber filter for your application.

Watch the video on how to install a hollow fiber filter into an XCell™ ATF 10 stainless steel device.

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