XCell SU 2_6.pngSimplify and intensify upstream bioprocessing with single-use convenience.
The XCell™ ATF  Single-use System delivers 100% cell retention and lab-to-production scalability without autoclave and lengthy setup steps.

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Simplify and intensify upstream bioprocessing with single-use convenience.

The XCell™ ATF Single-use System delivers the same superior performance as corresponding stainless steel XCell™ ATF Systems, but with significantly reduced implementation time.   Eliminated are the need for autoclave cycle development, autoclave cycle validation and pre-autoclave workflow.  The system is designed to work with the single-use workflows that are increasingly adopted in bioprocessing to realize flexibility, convenience and cost/resource savings.

  • Supplied with 0.2 µm Polyethersulfone or 0.2 µm Polysulfone hollow fiber filters
  • Fitted with convenient disposable aseptic connectors
  • Supplied gamma double-bagged and sterilized
  • Compatible with existing XCell™ ATF C24 and C410 Controllers
  • Same pump and diaphragm configurations as existing stainless steel XCell™ ATF Systems
  • Lightweight and stable

Webinar: XCell™ ATF 2 and ATF 6 Single-use

Both the XCell™ ATF 2 Single-use and XCell™ ATF 6 Single-use Systems exhibit similar cell growth, viability and cell-specific productivity compared to the same-size stainless steel XCell™ ATF Systems.

XCell™ ATF devices are supplied dry. To ensure robust filter performance, it is important to wet the filter prior to use.  The XCell™ ATF Tubing Set and the suggested wetting protocols are designed to:

  • Ensure efficient and complete filter wetting by minimizing the formation of air pockets during the wetting process
  • Enable pre-use filter integrity testing while maintaining sterility
  • Provide a means for evaluating the sterility of the XCell™ ATF device prior to establishing the bioreactor connection
  • Allow change-out of the XCell™ ATF device during a cell culture run without interrupting the bioreactor or XCell™ ATF operation

Two wetting procedures have been developed: an off-line procedure and an on-line procedure.  After filter wetting, a filter integrity test can be performed. Additional detail can be obtained in the XCell™ ATF Single-use User Guides.

Watch the video to see the XCell™ ATF offline wetting procedure.

SYSTEMS AND COMPONENTS

XCell™ ATF 2 Single-use Cell Retention System
XCell™ ATF 6 Single-use Cell Retention System
 

XCell™ ATF 2  Single-use Device
with C24 Controller

XCell™ ATF 6 Single-use Device
with C410 Controller

 

Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system.  We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.

LEARN MORE ABOUT REPLIGEN MANUFACTURING

XCell™ ATF 2 Single-use Device, 0.2,µm PS
Part Number suATF2-G02PS

XCell™ ATF 2 Single-use Device, 0.2 µm PES
Part Number suATF2-S02PES

XCell™ ATF 2 Single-use Stand
Part Number CS-10407

XCell™ ATF 6 Single-use Device, 0.2 µm PS
Part Number suATF6-G02PS

XCell™ ATF 6 Single-use Device, 0.2 µm PES
Part Number suATF6-S02PES

XCell™ ATF 6 Single-use Stand
Part Number CS-10359

XCell su tubingset.jpg

XCell™ ATF 6 Single-use Tubing Set
Part Number suATF6-TubeSetKit

The XCell™ ATF Single-use Devices are designed to be operated with the same controllers used in current  stainless steel XCell™ ATF Systems. No changes in configuration or connectivity of the controllers are required.

XCell™ ATF C24 Controller

for use with the XCell™ ATF 2 Single-use Device

XCell™ ATF C410 v4 Controller

for use with the XCell™ ATF 6 Single-use Device

XCell™ ATF C410 Controller Cart

for use with the XCell™ ATF C410 Controller

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