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Videos

Featured Video

Repligen Solutions from Gene to Therapy

Gene Therapy has immense potential to transform the lives of patients with genetic diseases. As demand for plasmids and viral vectors outpace capacity, a greater than 10-fold and potentially close to 100-fold increase in manufacturing efficiency for the gene therapy reagents is likely required to meet a demand curve that is increasing exponentially. Repligen solutions aim to meet the needs for optimized processes, higher yields, and improved process quality - setting new standards for modern scalable processes from gene to therapy.

Repligen Virtual Seminar | Overcome Bioprocessing Capacity Challenges

Repligen Virtual Seminar | Overcome Bioprocessing Capacity Challenges

Bioprocessing manufacturers are experiencing a surge in demand, and a need for novel solutions that enhance process economics and process optimizations. Led by plenary speaker Prof. J. Christopher Love, topics will include:

  • Strategic challenges and a vision for on-demand biomanufacturing
  • Capacity expansion initiatives to meet unprecedented demand
  • Viral vector manufacturing at scale
  • Upstream capacity expansion through cell retention based intensification
Configurability and Compliance for Automated TFF up to 500L

Configurability and Compliance for Automated TFF up to 500L

Driven by the rise in cell and gene therapies, TFF unit operations at scales from 10 mL to 500 L now require the single-use, automation and data integrity capabilities previously reserved for larger scale systems. The newly developed KrosFlo® KMPi TFF System from Repligen provides walk-away automation for concentration, diafiltration and fed-batch processes with TMP control, closed and single-use flow paths and 21 CFR Part 11 software compliance for processes up to 500L. Key components to this new system include: a patented automatic back-pressure control valve, a proprietary control board that enables plug-and-play hardware connectivity and modern software built upon a secure SQL database. Key technical features and applications supported by flexible configurations of the KrosFlo® KMPi TFF System will be discussed.

An improved workflow for miniaturized pre-packed columns and automation

An improved workflow for miniaturized pre-packed columns and automation

A workflow for automated chromatography process development created by Repligen, Tecan, and Synthace enables efficient design, deployment, and analysis of downstream purification strategies. Miniaturized OPUS® RoboColumn® Columns reduce resource demand and allow for parallelization of experiments. In conjunction with robotic liquid handling from Tecan and purpose-built automation software from Synthace, RoboColumn® Column users can optimize yield, purity, and reproducibility for expediting downstream development. The synergistic benefits of OPUS® RoboColumn® Columns, Tecan robotics, and Synthace software will be demonstrated in the context of a case study that would be unapproachable using traditional methods.

XCell™ Lab System for Simplified and Scaled-down Intensification

XCell™ Lab System for Simplified and Scaled-down Intensification

XCell ATF® technology can expand bioprocess facility capacity and throughput with cell densities up 300 x 106 VCD/mL. The newly launched XCell™ Lab Controller System accelerates development of robust intensified processes at volumes as low as 0.5L, reducing media costs per run and facilitating advancement to manufacturing. The benefits of key features such as a 0.5L single-use device, permeate pressure recording, a pump-based control logic loop, support for two devices per controller and a modern smartphone-like software interface are be discussed.

New COVID-19 Affinity Resin Purifies SARS COV-2 Spike Protein in One Step

New COVID-19 Affinity Resin Purifies SARS COV-2 Spike Protein in One Step

The new NGL COVID-19 Spike Protein Affinity Resin from Repligen binds the SARS CoV-2 Spike Protein receptor binding domain (RBD) to yield exceptional purity in a single chromatography step. Developed in partnership with Navigo Proteins and Purolite Life Sciences , the product meets all expected requirements of a high-performance resin, including very high selectivity, high dynamic binding capacities and caustic stability over multi-cycle use. Design features of the resin and example performance data will be discussed.

Technology-ready processes for Gene Therapy Manufacturing 2.0

Technology-ready processes for Gene Therapy Manufacturing 2.0

Repligen is ready to partner with gene therapy developers and manufacturers, providing technology breakthroughs and high impact solutions for plasmid and viral vector manufacturing.

May 12, 2020 | 11 minutes
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Automated High Throughput Viral Vector Purification to Streamline Downstream Process Development in Gene Therapy

Automated High Throughput Viral Vector Purification to Streamline Downstream Process Development in Gene Therapy

Learn how you can apply OPUS® Pre-packed Columns in different stages of viral vector manufacturing.

May 2020 | 17 minutes

Webinar: Effective Deployment of OPUS® PD Pre-packed Columns for Bench-scale Process Development and Process Validation

Webinar: Effective Deployment of OPUS® PD Pre-packed Columns for Bench-scale Process Development and Process Validation

Learn how to implement OPUS® Pre-packed Columns for automated parallel chromatography, bench-scale resin screening, process development, and sample preparation.

January 18, 2017 | 12 minutes
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Webinar: Scaling Up? No Problem with New 80cm Diameter Pre-packed OPUS® Columns

Webinar: Scaling Up? No Problem with New 80cm Diameter Pre-packed OPUS® Columns

Learn about OPUS® 80R Pre-packed Columns, the first and only pre-packed columns enabling the purification of over 10 kilos of protein in a single cycle.

April 18, 2018 | 18 minutes
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