Multiple Repligen-exclusive hardware and flow path innovations deliver increased product yield and operational success. Expert engineering minimizes product loss, enabling batch changes under 30 minutes while increasing yield and productivity. Systems seamlessly scale from 1/4” - 1” internal diameter (ID) tubing. Connectivity supports all major column formats, including full compatibility with OPUS® Pre-packed Columns.
Reduce hold-up volume with synergistic flow path and hardware
Connect seamlessly with OPUS® Pre-packed Columns
Execute more runs with batch change overs under 30 min
Systems scale from 1/4” to 1” flow path ID to support flow rates from 1 - 3000 LPH and OPUS® 8-80R Pre-packed Chromatography Columns. Consistent engineering and design across the platform facilitates scale-up development studies and technical transfer.
|System Flow Rate||1 - 180 L/H||6 - 1000 L/H|
|Column ID||8 - 25 cm||20 - 45 cm|
|Proprietary valve blocks||Minimize dead legs and hold-up volume (< 2D)|
|Over-molded connections||Reduce shear stress with constant bore ID, minimize leaks risk and process related impurities|
|Chromatography-specific valve manifolds||Maximize process yield with < 50% fill volume for precision gradient control|
|Filter-based air trap||Reduce hold-up volume with bubble trap alternative|
|Diaphragm pump||Lower shear stress, increase maximum pressure, redeuced pulsation|
|Full OPUS® Pre-packed Column compatibility||Accelerate implementation wtih plug-and-play columns: 10 cm - 80 cm internal diameters|
Pre-assembled chromatography flow paths integrate advanced fluid management technologies, including injection molding, over-molded connections, pump heads, tubing, filters and sensors in a strong, nearly leak-free, closed and single-use device. Designed for simplicity, flow paths install in less than 30 minutes and increase process efficiency.
Valve Block Components
Innovative valve blocks direct fluids through uniform ID, crevice-free flow paths, achieving extremely low turbulence. Multiple T injection-molded silicone inserts, combined with over-molded connections, minimize footprint and enable optimum closure point placement, significantly reducing dead leg.
Traditional hose-barbed manifold
Artesyn® molded manifold
|Input voltage||110 - 240 VAC 50/60 Hz 1 Φ, 15A supply|
|Ingress protection||IP45, pump head IP25|
|Compressed air||5 - 6 bar, oil and particle free|
|Operating temperature||2 - 50º C, Relative humidity 10 - 90% (Non-condensing)|
|Fluid temperature||2 - 40º C|
|Maximum operating pressure||4 bar|
|Compliance||UL and CE certified|