Reduce in-line turbulence and gradient dilution for improved resolution and recovery
Valve blocks and injection molded tubing junctions help reduce mechanical stress to the product
Pre-assembled flow kits and simpler batch changes reduce human error and contamination events
Maintaining gradient control from the mixing valve to the column and protecting peak resolution is critical to maximizing recovery, but can be challenging with traditional systems. Dilution, turbulence and dead-legs can all occur along the flowpath and disrupt the process. Repligen has developed technologies specifically targeted to eliminate or minimize those challenges.
Traditional bubble trap
Up to 500ml of hold-up volume can uncontrollably disrupt gradient, causing back mixing and dilution, harming reproducibility and recovery.
Repligen filter and level sensor solution
Traditional valve solutions at tubing junctions
Valve block technology
Traditional solutions utilize hose barbs, zip ties and individual valves at tubing junctions causing excess shear stress to the product as inner diameter narrows and flow dips into significant dead legs.
The consistent ID of overmolded connections coupled with injection molded tubing and valve block hardware at critical junctions eliminate dead-legs, minimize shear stress and protect product integrity.
Repligen has simplified user experience and minimized risk during batch changes reducing equipment downtime and saving valuable resources.
Flow path arrives in four gamma irradiated sub-assemblies.
Ready to go
Batch change on traditional single-use chromatogrpahy systems can be resource intensive, require hours, tie up more than one person and necessitate many more manual interactions during installation increasing overall risk.
Repligen has developed or acquired multiple chromatography technologies that in conjunction with our systems work to further increase operational efficiencies for your process and facility.
|Flow rate||1 - 180 L/h||6 - 900 L/h||25 - 2000 L/h||50 - 3600 L/h|
|Column size||8 - 25 cm ID||20 - 45 cm ID||45 - 80 cm ID||60 - 80 cm ID|
|Pump type||2 Quattroflow™ pumps|
2 flow meters
|Software||AB PLC and Wonderware|
|Multiple flow paths||One built for purpose flowpath on each system for optimal process efficiency|