Any size, any resin, ultimate flexibility
With thousands of columns shipped globally each year, OPUS® 5 - 80R Pre-packed Chromatography Columns lead the way with unparalleled flexibility in media choice, application, and size. Since launching OPUS® Columns in 2012, Repligen is the recognized expert in packing manufacturing-scale columns today, and the innovation leader in downstream pre-packed column technology.
Volume from 0.1 L to 150 L
Bed height from 5 cm to 30 cm, configurable to the nearest milimeter
Packed with user-specified resin; over 100 resins available for OPUS® 5 - 80R
Breakthrough innovative side port for resin unpacking for OPUS® 45R, 60R, 80R
Pre-packed columns provided ready to use; no cleaning validation process; no column packing failures
Up to 35% cost savings over self-
packed columns; up to 150 FTE hours savings per campaign; no upfront capital expense; faster campaign turnarounds
ISO 9001 quality manufacturing;
complete documentation package
for GMP use
Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.
OPUS® 80R is the first and only pre-packed column enabling the purification of over 10 kilos of protein in a single cycle.
OPUS® Pre-packed Chromatography Columns offer unparalleled flexibility in media choice, application and size. Applying the most advanced pre-packed chromatography column technology available today, OPUS® columns are ready-to-use alternatives to traditional self-packed columns.
|Partial List of Resins for OPUS® 5 - 80R|
IEX/Mixed Mode Resin
IEX Capto™ ImpRes: SP and Q
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In response to the need to scale up chromatography processes, Repligen offers the largest pre-packed columns for the bioprocess industry. OPUS® 45R, 60R and 80R Columns are the first pre-packed columns designed to meet the chromatography requirements of larger 1000L and 2000L single-use bioreactors.
Introducing OPUS® 80R, the latest innovation from the Leader of the Pack
The first and only 80 cm diameter pre-packed column, OPUS® 80R can be configured with bed heights from 10-30 cm and is capable of purifying over 10 kilos of protein in a single cycle.
|OPUS® 45R||OPUS® 60R||OPUS® 80R|
|Internal diameter||45.7 cm||59.9 cm||79.9 cm|
|Column body pressure rating||3 bar||3 bar||3 bar|
|Bed height range||10 - 30 cm||10 - 30 cm||10 - 30 cm|
|Column volume: 20 cm bed height||33 L||56 L||100 L|
|Assembled column height||≤ 20 cm BH: 90 cm (35 in)
> 20 cm BH: 116 cm (45 in)
|≤ 20 cm BH: 93 cm (37 in)
> 20 cm BH: 120 cm (47 in)
|≤ 20 cm BH: 97 cm (38 in)
> 20 cm BH: 123 cm (48 in)
|Assembled column width||47 cm (18 in)||61 cm (24 in)||81 cm (32 in)|
|Assembled column depth||54 cm (21 in)||68 cm (27 in)||91 cm (36 in)|
|Inlet/Outlet flow path internal diameter||12.7 mm (0.5 in)||19.1 mm (0.7 in)||19.1 mm (0.7 in)|
|Inlet/Outlet port connection (per ASME BPE standards, current ed.)||½" sanitary connector||1" sanitary connector||1" sanitary connector|
|Estimated weight @ 20 cm BH||68 kg (150 lbs)||160 kg (350 lbs)||310 kg (690 lbs)|
From pre-packed to unpacked
With an innovative side port that allows for easy resin unpacking, OPUS® 45R, 60R, and 80R Columns provide the ultimate flexibility in pre-packed column technology.
Without compromising chromatographic performance or cleanability, the new feature helps mitigate the risk of implementing pre-packed columns in GMP settings, and allows for re-use of the unpacked resin in other columns.
Simple unpacking procedure
A simple procedure allows for complete recovery of resin in ≤ 5 column volumes. The OPUS® 45R, 60R, and 80R unpacking procedure includes the introduction and cycling of liquid and air between the existing column inlet and outlet ports. The process is repeated until only air is evacuated from the unpacking port.
Watch the video to see how an OPUS® 60R Pre-packed Column is unpacked.
Substantial savings in manufacturing costs and labor are realized because OPUS® Columns offer the benefits that come with pre-packed technology:
The OPUS® Calculator can help you estimate how much you can save when using OPUS® columns in your specific application.
In this example, over 65% cost savings and up to 80% labor savings were achieved when using OPUS® Columns compared to self-packed columns.
OPUS® Columns are the result of expert engineering combined with deep industry knowledge and experience in downstream chromatography.
OPUS® Columns are designed for use in GMP environments for the manufacturing of clinical and commercial biologic drugs.
From quote request to routine use in GMP processes, OPUS® Columns go through rigorous quality control and validation.
A convenient resin pick-up service is available upon approval.