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2x lentiviral bioreactor yield increase with best-in-class operational simplicity 

View the published article by Oxford Biomedica and Repligen discussing how TFDF® Technology enabled greater than 200% increase in lentiviral bioreactor harvest yield.

Lentiviral vector manufacturing process enhancement

utilizing TFDF® technology

  • TFDF® filtration technology successfully separates cells and debris from HIV-GFP and lenti viral vectors​

  • Overall >200% harvest yield increase compared to depth filtration​

  • > 90% yield at  700–750 liters/m2/hour (LMH)​

  • Scaled from 5 and 50 L scales​

  • Low shear enabled multi-harvest, perfusion mode productivity gains