Materiality

At Repligen, we value monitoring emerging issues material to our business and our value chain, assessing related topics according to new information and evolving stakeholder expectations. We aim to review our Materiality Matrix annually to ensure that our team is focused on the most important issues and opportunities for impact. This helps us to stay closely aligned with stakeholder priorities and relevant regulations that influence the rapidly evolving bioprocessing industry.

In 2024, we continued to lead and participate in numerous stakeholder communications across the business with key customers, critical suppliers, leading institutional investors and employee resource groups. This engagement helped us understand their interests, priorities, targets and challenges through the increasingly relevant lens of sustainability. The Materiality Matrix on this page summarizes Repligen Corporation’s materiality assessment, which aligns with our foundational four pillars of sustainability, the 4Ps first introduced in our inaugural 2020 corporate sustainability report, “Committed to Making a Difference.”

Scope 3 Materiality

The second table on this page summarizes our assessment of material Scope 3 emissions categories. Here we highlight the 11 categories, of 15 total categories, that are material to Repligen. We started reporting on two of these categories, category 6 (Business Travel) and category 7 (Employee Commuting), in our inaugural 2020 report. In our 2022 report, we added emissions data for seven additional categories, bringing the total to nine. And with our 2024 report, we have included partial data for the two remaining material categories, category 11 (Use of Sold Products) and category 12 (End-of-Life Treatment of Sold Products). While these last two emissions inventories include data for select Repligen products only, significant progress was made toward building out the process map for other product lines. We look forward to elevating our Scope 3 emissions reporting for 2025 and beyond.

Materiality Matrix

In 2024, we reviewed the materiality assessment and Scope 3 categories reflected on this page according to our 4Ps and reaffirmed them. Additionally, we will perform a double materiality assessment in 2025 to update this information and align with the European Union’s new Corporate Sustainability Reporting Directive (CSRD).

matrix

Material to Repligen

  COMMUNITIES CUSTOMERS EMPLOYEES INVESTORS SUPPLIERS

Principles

Working Responsibily
Business Ethics & Compliance
Enterprise Risk Management  
Financial Integrity      
Cybersecurity & Data Privacy    
Partner (Supplier) Ethics & Compliance        

People

Caring About Our Employees and Communities
Health, Safety & Well-Being  
Diversity, Equity & Inclusion    
Employee Attraction, Development & Retention      
Community Engagement & Impact      
Labor Practices

Product

Innovating Through a Sustainability Lens
Innovation  
Supply Chain Management    
Product Quality & Safety      
Product Design & Lifecycle Management  

Planet

Protecting the Environment
Environmental Impact
Energy Use & Climate Impact
Water Use    
Solid Waste Management      

Principles

Working Responsibly
  COMMUNITIES CUSTOMERS EMPLOYEES INVESTORS SUPPLIERS
Business Ethics & Compliance
Enterprise Risk Management  
Financial Integrity      
Cybersecurity & Data Privacy    
Partner (Supplier) Ethics & Compliance        
Material to Repligen

People

Caring About Our Employees and Communities
  COMMUNITIES CUSTOMERS EMPLOYEES INVESTORS SUPPLIERS
Health, Safety & Well-Being  
Diversity, Equity & Inclusion    
Employee Attraction, Development & Retention      
Community Engagement & Impact      
Labor Practices
Material to Repligen

Product

Innovating Through a Sustainability Lens
  COMMUNITIES CUSTOMERS EMPLOYEES INVESTORS SUPPLIERS
Innovation  
Supply Chain Management    
Product Quality & Safety      
Product Design & Lifecycle Management  
Material to Repligen

Planet

Protecting the Environment
  COMMUNITIES CUSTOMERS EMPLOYEES INVESTORS SUPPLIERS
Environmental Impact
Energy Use & Climate Impact
Water Use    
Solid Waste Management      
Material to Repligen

scope 3 emissions categories

Material to Repligen

  • 1 Purchased goods and services
  • 2 Capital goods
  • 3 Fuel- and energy-related activities
  • 4 Transportation and distribution (upstream)
  • 5 Waste generated in operations
  • 6 Business travel
  • 7 Employee commuting
  • 8 Upstream leased assets
  • 9 Transportation and distribution (downstream)
  • 10 Processing of sold products
  • 11 Use of sold products
  • 12 End-of-life treatment of sold products
  • 13 Downstream leased assets
  • 14 Franchises
  • 15 Investments

Methodology

01
  • GHG Protocol Guidance was used for all emissions accounting, and market-based emission factors were utilized for the calculations.
  • The U.S. Environmental Protection Agency (EPA) Emissions and Generation Resource Integrated Database (eGRID) and EPA Energy Information Administration (EIA) data were used to prepare our emissions inventories.
  • EPA Global Warming Potential (GWP) values were used to standardize all emissions by carbon dioxide equivalents (CO2e).
  • Energy usage and GHG emissions metrics are based on utility invoices of purchased energy, best estimates from property managers of shared rental spaces and in-house calculations from site-level data.
  • The annual impact of direct renewable electricity purchases and renewable energy credits (RECs) on our total GHG emissions is based on aggregate market-based site-level data.
  • Water withdrawal metrics are based on utility invoices and used as a proxy for consumption data. At our one site that is supported by well water, metrics are derived from expected baseline usage.
  • Water discharge metrics are tracked for water that is used in manufacturing processes and treated before discharge.
  • Waste metrics are predicated on hauler invoices, regular service provider reporting and in-house calculations.
  • Employee-related data covers all Repligen sites, unless otherwise indicated.
  • Annual voluntary commuting surveys directly inform our global Scope 3 category 7 (Employee Commuting) emissions data.
02

The Repligen ESG Ambassador network is responsible for collecting and monitoring site-level data on an ongoing basis while our corporate Sustainability team oversees uploads to our financial-grade ESG software platform.

03

Other than audited financial data, the content of this report has not been externally verified. However, the feasibility of third-party assurance is under evaluation for future installments of our corporate sustainability report.

04

Any financial data sets in this report are historical only and have been fully audited by our independent registered public accounting firm based on criteria established in Internal Control — Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (2013 framework). All financial information in this report is limited to continuing operations and is reported in U.S. dollars.

For more information about Repligen Corporation’s approach to sustainability and ESG reporting, email us at [email protected].