Continuous buffer flow

No manual buffer changes

Walkaway convenience


Includes dialysis tank, pump, reservoirs, membrane

Fast implementation time


Scale up from lab to process scale

Scale out from 1 to 6 tanks in series

Increased purification efficiency

Sealed self-enclosed design

Minimized exposure to external contaminants

Innovative mobile system 

Large-scale, small footprint

Series operation conserves buffer

Dynamic Dialysis

Dynamic dialysis is an exciting new technology that utilizes fluid dynamics to increase purification efficiency and improve large buffer handling, ideal for the production of fragile proteins, viscous fluids and polymer gels, such as hyaluronic acid. These closed, high-efficiency systems offer high concentration gradient dialysis without manual buffer changes and in-process sample handling.

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SpectraFlo™ Dynamic Dialysis Systems

SpectraFlo™ Lab System

10-200 ml

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SpectraFlo™ Process System

150 ml - 2 L

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SpectraFlo™ Mobile Dialysis System

6 - 12 L

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Dynamic Dialysis Applications

Dynamic dialysis is ideal for the purification of viscous fluids and hydrogels (hyaluronic acid – HA) that cannot be filtered. Where traditional filtration methods may fail, dynamic dialysis uses flow dynamics to increase both the rate and efficiency of dialysis.


Why Dynamic Dialysis is preferred


Delicate samples

Gentle separation without shear stress

Labile proteins and intact viruses

Viscous samples (Hyaluronic Acid)

Process hydrogels that are too viscous for filtration

Cross-linked Hyaluronic Acid for aesthetics and orthobiologics

Protein refolding

Refold proteins to native state using gradual pH
change through buffer flow

Overexpressed proteins containing inclusion bodies

High debris lysate

Will not foul like pressure driven filtration

Demineralized bone matrix for othopedic surgery

Polymer and Biopolymer synthesis

Low MWCO enables removal of unbound low
molecular weight monomer

Oligonucleotides and polypeptides

Scale up of any static dialysis application

Easy scale up without complex validation or
financial burden of filtration


Tank Sizes

SpectraFlo™ Modes of Operation

Case Study: Model of Dynamic Dialysis

This model of a GMP batch production of shear-sensitive protein shows an efficent scale-up of large volume dynamic dialysis for purification. 

SpectraFlo™ Mobile Features and Benefits

Up to 6 tanks in series Scale up to 12L Sample Size
Parallel or series operation Optimize buffer usage
Wet work tray Prepare and load samples with secondary containment
Drain manifold Load and drain buffer easily
BSE/TSE free polypropylene construction Use for GMP processes and cleanroom manufacturing
Collapsible shelves and tubing hooks Store complete system in compact space


KR1 Peristaltic Pump

600 RPM pump-drive with multi-position pump-head

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Processing Reservoirs

Designed with drain and 4 ports for recirculating or reservoirs in series

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Double sample capacity with 2 dialysis tubings in each tank. 

*Tank not included.

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Cap Kit

Optional for process system, required for mobile system

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Replacement parts

Pump tubing, gasket sets, hose barbs and stands

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Closure Kit

For proper membrane handing
and support

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Cart Design

Materials of Construction

Quality Specifications

  • USP Class VI biosafety requirements
  • 21 CFR 177.1520
  • Phthalates, BPA and DEHP free
  • BSE/TSE free

Quality Management System-ISO 9001:2015