Ready-to-operate single-use simplicity

Complete with filters, fittings, connections, reservoirs, transducers

Quality Manufacturing

Expert project management

Defined lead times

In response to the demand to improve process efficiencies, ProConnex® Flow Paths from Repligen provide customized, configurable and complete assemblies with ready-to-use convenience. Benefits include improved batch control, no cross-contamination, lower production costs, reduced manufacturing down-time, quicker and easier set-up time.

Build a ProConnex® Flow Path around a Spectrum® Hollow Fiber filter, TangenX® Cassette or TFDF® Filter. ProConnex Flow Paths are designed according to specific customer specifications by Repligen engineers for a specific application. They are intuitively designed for simple, mistake-free installation. All system sensors are pre-calibrated and assembly is done in minutes with no confusing instructions.


Turn design ideas into engineering plans in minutes

Take a flow path idea to a preliminary engineering drawing in minutes with an on-line digital configurator and expert consultation. Leverage drag-and-drop capabilities and a library of over 250 individual components to create an engineering drawing illustrating the specific needs of your application.

  • Rapid pricing based on configurator output
  • Design lock and final pricing done by team of engineering specialists

Speak to an Expert


Technical consultation from concept to product 

With decades of experience, Repligen technical experts match your core technology with the flow paths that suit your application.

Process goals
Core technology, application, facility fit

Process parameters
Feed flow rate​, working volume​ and pressure​, integrity test​, sterility​, scale

Flow path requirements
Aseptic connectors​, sensors​, vessel​, hold-up volume 

Flow path specifications
Engineering documents​, bill of materials​, design lock

ProConnex® Flow Paths

ProConnex® Flow Paths are customized, configurable and complete single-use assemblies that are pre-assembled to optimize connectivity with industry standard filtration technology and workflow. The self-contained design of ProConnex Flow Paths reduce implementation time, are Gamma-irradiated to lower the risk of contamination and are built to meet the demands of customer-specific filtration applications. 

Click on the tabs to explore features of the different ProConnex Filter Assemblies available today.

For use with

KrosFlo® RS Systems

KrosFlo® FS Systems


Click on the links to explore components of the ProConnex® Flow Path.


Click on the left/right arrows or swipe to see flow path assembly steps for the different KrosFlo® RS TFF Systems.




For use with

KrosFlo® KR2i Systems

KrosFlo® KMPi Systems

KrosFlo® KTF Systems

Click on the links to explore components of the ProConnex® Flow Path.

For use with

KrosFlo® TFDF® Systems

Click on the links to explore components of the ProConnex® Flow Path.

Single-use, Gamma-irradiated and closed ProConnex® TFDF® Flow Paths arrive dry, free of sodium hydroxide, glycerin, preservative and ethanol, for a zero flush start state. 

TFDF® 30 Filter
Surface Area: 30 cm2

ProConnex® TFDF®
Flow Path
Surface Area: 30 cm2

ProConnex® TFDF®
Flow Path
Surface Area: 150 cm2

ProConnex® TFDF®
Flow Path
Surface Area: 1500 cm2

ProConnex® TFDF®
Flow Path
Surface Area: 6000 cm2

Industrial grade components and extended automation allow for confident process scaling. With the same software, hardware, controls and cGMP compliance built into every system, process change challenges in scale-up are removed.

For use with

KRM Chromatography Systems


Click on the links to explore components of the ProConnex® Flow Path.


Watch Flow Path installation on the KRM™ 20 Chromatography System.

Manufacturing Centers of Excellence

Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.

Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands,  Germany and Estonia.


Customer First.

Support is part of the Repligen DNA. Our goal is to provide exceptional customer experience, and to support the efficient and successful adoption and implementation of all Repligen products and services.

  • Field Application Support
  • Customer Service
  • Field Service Engineers

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