Hollow Fiber Filters
Ideal for ultrafiltration, diafiltration and microfiltration, single-use hollow fiber filters for tangential flow filtration are packed in housings engineered to handle high pressures, with a choice of fiber chemistries and sizes from process development to manufacturing.
Maximized performance
Gentle on shear-sensitive product
Emphasis on Efficiency
MAXIMIZED PERFORMANCE
Gentle on shear-sensitive molecules
Hollow fibers possess a smooth internal wall and tubular channel geometry, that promotes laminar flow with high flux. The low shear and turbulence of laminar flow helps maintain the integrity of shear sensitive modalities such as lentivirus.
Laminar flow
Flow is primarily straight and streamlined
Turbulent flow
Irregular, chaotic flow creates eddies that change flow in both magnitude and direction
MAXIMIZED PERFORMANCE
Game-changing mPES Chemistry
Directly modified from the PES backbone
- Uniquely formulated to provide tight selectivity without sacrificing high flux
- Thin selective layer in the inner lumen
- Significantly s more porous membrane
- Robust design for high-pressure applications
- Ideal for Lentivirus, mRNA, pDNA and LNPs
- Maximizes recovery
- Reduces fouling
Find your filter configuration Request a Quote
Membrane Applications
The following table shows typical use of membrane chemistries by application.
EMPHASIS ON EFFICIENCY
Emphasis on manufacturing innovation and security of supply
State-of-the-art facility
- ISO 9001 certified
- ISO 7 cleanroom
High degree of automation
- Hight throughput
- Consistency in quality
Competitive lead times
- Select off-the-shelf filters
- Available with or without gamma irradiation
END-TO-END EXPERTISE
Leverage TFF expertise in filter selection and beyond
- Selection of TFF format: Heavily reliant on modality
- Screening membrane MWCO: Selection based on recovery and impurity removal
- Final TFF condition optimization and sizing for process scale-up: Flux optimization and sizing at different scales
Scale-up made easy
Hollow fiber filter TFF modules are offered with a broad range of sizes, surface areas and membrane chemistries designed to facilitate easy scale-up from small volume process development and R&D applications to commercial production. During scale-up, adding more fibers to process larger volumes enables consistency in the length of the filtration flow path even while the surface area of the filter is increased.
Primary Application | Volume | Inlet/ Outlet | Side Port | Effective Length (cm) | Total Length (cm) | Surface area | |
---|---|---|---|---|---|---|---|
MicroKros |
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Process characterization, Small-volume TFF in a laboratory | 1-100 ml | MLL | FLL | 20 41.5 65 |
25 45 69 |
13 – 20 cm2 26 - 59 cm2 41 - 92 cm2 |
|
MidiKros |
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Process development at small scale | 100 ml - 3 L | FLL | FLL | 20 41.5 65 |
25 45 69 |
75 – 190 cm2 155 - 390 cm2 245 - 610 cm2 |
|
MidiKros TC |
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Process development at pilot scale | 100 ml - 3 L | 1/2" TC | FLL | 20 41.5 65 |
25 45 69 |
75 – 190 cm2 155 - 390 cm2 245 - 610 cm2 |
|
MiniKros Sampler |
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Batch TFF of small volumes | 3 L -15 L | 0.75" TC | 0.75" TC | 20 41.5 65 |
25 47 70 |
490 – 1000 cm2 1000 - 2200 cm2 1600 - 3400 cm2 |
|
MiniKros |
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Pilot-scale TFF | 5 L - 50 L | 1.5" TC | 0.75" TC | 20 41.5 65 |
25 46 70 |
0.16 - 0.31 m2 0.32 - 0.65 m2 0.51 - 1.0 m2 |
|
KrosFlo® |
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Production-scale TFF | 10 – 100L | 3" TC | 1.5" TC | 20 41.5 65 |
23 46 69 |
0.78 - 1.6 m2 1.65 - 3.25 m2 2.55 - 5.10 m2 |
|
KrosFlo® MAX |
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Request a Quote | Production-scale TFF | 100L – 1000+L | 6" TC | 1.5" TC | 49.9 67.9 107.5 |
73.5 91.5 131.1 |
4.30 - 10.40 m2 7.10 - 17.10 m2 11.30 - 11.35 m2 |
Configurators
Product Number Key
To specify the hollow fiber filter specific to your application, follow the product number key below.
Click on the image highlights to see the different elements of lab-scale and commercial-scale TFF Solutions from Repligen