Solutions
Optimize Downstream Processing
Downstream performance depends on more than any single unit operation. From chromatography and UF/DF through formulation and fill-finish, every step influences the next.
Improve process productivity and facility efficiency
At Repligen, we are revolutionizing the way biotherapeutics are manufactured. Our advanced downstream processing solutions are designed to maximize process productivity, enhance facility efficiency, and help you deliver life-changing therapies with confidence. Discover how our innovative product lines can transform your operations.
Build a downstream process that is easier to scale, transfer, and control
Downstream processing is the part of biologics manufacturing that purifies, concentrates, formulates, and prepares a biologic for final fill-finish and delivery. It plays an essential role in yield, product quality, process control, and how reliably a process can scale into GMP manufacturing.
For bioprocess, MSAT, and manufacturing teams, strong downstream processing makes it easier to reduce variability, support tech transfer, improve batch consistency, and run a more predictable workflow from development through commercial production.
Downstream performance depends on how well the process works together
Each downstream step contributes to performance, but the way those steps connect is what determines how well the process runs overall.
Changes in purification affect concentration. Variability in UF/DF carries into formulation. Small inconsistencies early in the process can create larger challenges later on.
For process development, MSAT, and manufacturing teams, this leads to a practical outcome: a downstream process that is easier to understand, easier to scale, and easier to run with confidence.
A more effective approach focuses on the workflow as a whole:
Creating consistency between step
Reducing variability as the process scales
Improving visibility into what’s happening in real time
Making processes easier to transfer and operate
Products
Downstream Filtration
Concentrate, clarify, and purify biologics with scalable tangential flow filtration solutions built for development through commercial manufacturing.
Chromatography
Increase purification efficiency with systems, pre-packed columns, and resins engineered for modern biologics manufacturing.
Fluid Management
Own your process with ProConnex® — streamlined fluid management solutions that reduces risk, improves consistency, and accelerates your path to production.
Process Analytics
Gain faster answers and stronger process control with real-time process analytical technology that drives confident decisions.
How it comes together in your downstream workflow
Downstream works best when each step supports the next. Repligen connects capture, polishing, concentration, and monitoring so your team can manage the full sequence with more continuity and fewer disruptions.
- Capture and polishing chromatography
- Virus filtration
- UF/DF, concentration, and buffer exchange
- Real-time process analytics and control
- Single-use fluid management and flow paths
- Scale-up support from process development to commercial manufacturing
Frequently asked questions
Get quick answers on how Repligen supports downstream processing—from recovery and purification to real-time control and scale-up.
Upstream processing produces the biologic (cell culture, expansion, harvest). Downstream processing purifies, concentrates, and formulates it after harvest—through chromatography, virus filtration, UF/DF, and final formulation—to prepare it for fill-finish.
Ultrafiltration/diafiltration (UF/DF) uses tangential flow filtration to concentrate a product and exchange it into its final buffer. It's a critical downstream step for yield, product quality, and formulation consistency.
Consistent unit operations, connected data, and reproducible chromatography and UF/DF make scale-up predictable. Repligen supports the same technologies from process development through commercial manufacturing to reduce tech-transfer risk.
Product loss drops when each step protects the molecule. Gentle TFF, consistent chromatography, and real-time concentration control help hold recovery high across capture, polishing, and UF/DF.
Why teams choose Repligen for downstream processing
Repligen brings together downstream expertise, enabling technologies, and hands-on support to help you solve real process challenges—not just supply equipment. The goal is straightforward: make complex downstream decisions easier to manage so your program keeps moving forward.
- Connected solutions across purification, UF/DF, analytics, and fluid management
- Consistent performance from development to commercial scale
- Real-time process visibility and control
- Global application and technical support