KrosFlo® KPS Tangential Flow Filtration (TFF) Systems
The KrosFlo® KPS System is engineered for cell culture perfusion operations, delivering a broad range of flow rates, robust automation, and single-use flexibility for process development through manufacturing. Built on decades of tangential flow filtration (TFF) expertise, KrosFlo KPS systems are highly configurable combining operational flexibility and gentle cell culture process handling.
SIMPLIFY AND INTENSIFY
Configurable while delivering high throughput
Permeate pressure data for improved characterization
Integrated pressure sensors
INTERGRATED
All-in-one solution- filter, flow path and system
SCALABLE
Maintain processes while scaling from process development to pilot
Expandable Filter Capacity and Adaptive Recipe Editor for High-Density Perfusion
The KrosFlo® KPS system is designed for flexible process scale-up, enabling you to increase capacity simply by adding more filters as your production needs grow. KlariFi™ software supports this scalability with a configurable recipe editor—allowing you to tailor process parameters, such as the number of filters, to match your specific requirements. As cell densities rise and media demand increases, you can seamlessly expand your setup by integrating additional filters, ensuring consistent performance and high product yield.
Unlike other systems, KlariFi’s recipe editor is uniquely capable of adapting recipes in real time based on process scaling and shear rates. This means you can modify operational settings to optimize cell viability and product quality as your process evolves—giving you unmatched control and flexibility for perfusion applications.
Precision Personalized
Integrate the KrosFlo KPS system directly onto your bioreactor or SCADA network for data centralization and streamlined operations. Want to monitor and control your process directly on the system? The KrosFlo KPS can be configured to operate using our user-friendly, recipe-driven automation platform KlariFi™.
Wide Range of Hollow Fiber Filter Selection
To unlock the full potential of the KrosFlo® KPS system, pair it with Spectrum® Hollow Fiber Filters—purpose-built for reliable cell retention in upstream perfusion. Engineered for seamless integration, Spectrum filters deliver exceptional viability, low-shear handling, and consistent performance even at high cell densities. Together, they form a robust, closed-loop TFF solution that supports high product yield, and scalable operation from development through production.
Prevent Batch Loss with Built-in Redundancy
With KrosFlo KPS systems, filter fouling doesn’t have to result in loss of batches. Thanks to the innovative dual pump configuration, operators can isolate a fouled filter line and seamlessly swap in a new filter without disrupting the process. This built-in redundancy provides added peace of mind, even when runs don’t go according to plan.
Upstream Bioproduction Expertise
With decades of perfusion design experience, viral vector clarification, N‑1 intensification, and seed train compression, Repligen field application scientists and system engineers collaborate with you to turn upstream intensification ambitions into a reality.
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