Modularity Made Easy with Plug-and-Play Configurability

KrosFlo® KR2i TFF systems achieve an unparalleled combination of configurability and user-simplicity through modular, plug-and-play hardware.  All components, either directly or indirectly, connect to the main pump, which then communicates with the KF Comm 2 software for control and monitoring. 


More Capabilities, Still Simple.

Get more out of TFF with the flexibility to configure your system to better suit your application needs. Keep your process compact and minimal or expand your capabilities to more advance modes of operation by adding components. Switch back and forth between configurations all without compromising on ease of use.


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Automate, Control and Visualize with KF Comm 2

Control the whole system, configure recipes and automate processes in as little as 4 clicks through the intuitive KF Comm 2 software

  • Conveniently installed on any device using the Windows Operating System 
  • Compatible with Chrome, Mozilla, Firefox and Microsoft Explorer browsers
  • Automatic software and firmware updates
  • Optional 21 CFR Part 11 package available 


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Still using legacy KF Comm software?    Upgrade now


Walk-away automation for your lab

The days of manually adjusting screw clamps are over. A Repligen-exclusive technology, the Automatic Back Pressure (ABV) Valve adds transmembrane pressure (TMP) control to every TFF process, reducing operator hands-on-time, data logging and continuous monitoring while improving process reproducibility. 

  • Automatically adjust tubing pinch distance according to user-defined set-points
  • Maintain uniform TMP throughout process run, decreasing membrane fouling
  • Use with compatible tubing sizes 13, 14, 16, 25, HP15, 17, HP24, 18, HP35, 36, and HP36

KrosFlo® KR2i Virtual Demo Series

In this 6-part series, Julie Grace, and Carl Breuning, provide viewers with a virtual training on the KrosFlo® KR2i TFF system. This training series will cover the following topics:

  • Introduction to system components
  • Installation of flow-path and filter
  • KF Comm2 software overview
  • Recipe creation
  • Running a CFC/D/C experiment
  • Recovery of product


Standard and Configurable ProConnex® Flow Paths

ProConnex® Flow Paths are customized, configurable and complete assemblies for tangential flow filtration.  Designed for use with hollow fiber and/or flat sheet TFF systems, the assemblies are sterile, fit for upstream or downstream processing and manufactured in compliance with ISO guidelines in an ISO 7 clean room.

ProConnex® Flow Paths       Shop now


Effortless scaling with a single standardized platform  

Designed as a platform and not as standalone units, KrosFlo KR2i, KMPi, and FS lab scale TFF systems share the same components, software and controls across the entire family, allowing you to confidently standardize your process. Common process change challenges during scale-up are removed.



TFF with In-Line Protein Concentration Management

No longer are you dependent solely on mass inputs and off-line fixed-pathlength UV-Vis spectrophotometers. Now, you can measure what truly matters in real-time with the KrosFlo® KR2i RPM™ System. Monitor concentration in real time during your UF/DF run and control your process. 

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System features at a glance

The fully integrated KrosFlo KR2i TFF System features a digital peristaltic pump, graphical LCD display, digital pressure monitor, KR2i Pump head, automatic backpressure valve, filter module stand, and KF Comm real-time data collection software.

Highly configurable and versatile, the KrosFlo KR2i utilizes a number user-defined set-points to run complex application processes with numerous built-in safety alarms and stops. The system can run up to two stackable pump heads for higher flow rates.

Click on the links below to explore different features.

Components and Accessories

  • IP 33 Enclosure
  • 600 RPM pump with reversible drive
  • 90-260 Vrms @ 50/60 Hz
  • Standard Easy Load 3 Pump Head for precision tubing L/S number 13, 14, 16, 25, 17, and 18 provided.
  • (Optional) Easy Load 3 pump head for high performance tubing L/S numbers 15, 24, 35, 36
  • ETL listed and CE/UL/cUL marked
  • Pump Drive Dimensions: 10.5 in x 8 in x 8 in

Konduit adds:

  • End point conductivity control for UF /DF
  • End point UV control for diafiltering free drug from drug delivery particles
  • End point UV control for concentration of certain molecules
  • UV alarm for membrane breakthrough
  • A260 and A280 light sources available

*UV components sold separately


Maintain user-defined feed weight set-points, and total permeate mass during TFF processes.

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KrosFlo® KR Jr Auxiliary Pump

Auxiliary pumps automatically increase or decrease buffer/product addition to feed reservoir.

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  • Measures and displays 4 pressures: Feed Pressure, Retentate Pressure, Permeate Pressure, Transmembrane Pressure (TMP)
  • User-defined pressure alarms and stop set-points
  • Available with different connector types (Luer and TC)  and selected materials of construction (PS, PC)

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Manufacturing Centers of Excellence

Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.

Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands,  Germany and Estonia.


Customer First.

Support is part of the Repligen DNA. Our goal is to provide exceptional customer experience, and to support the efficient and successful adoption and implementation of all Repligen products and services.

  • Field Application Support
  • Customer Service
  • Field Service Engineers

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