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KrosFlo® TFF Systems
Turnkey systems for tangential flow filtration (TFF), KrosFlo® Systems are compatible with single-use hollow fiber filters and/or flat sheet cassettes, modernizing how UF/DF is performed at every stage from process development to large-scale manufacturing.
Discover your next KrosFlo® Tangential Flow Filtration System
Automated tangential flow filtration systems for bench scale from 5mL - 500L
Foundational to research and process development laboratories globally, KrosFlo® KR2i, KMPi, and FS systems are proven and intuitive TFF solutions for testing and optimizing procedures for scale up.
KrosFlo® FS TFF Systems
Fully automate flat sheet TFF processes up to 500 L with configurable hardware components that deliver an unparalleled combination of automation, configurability, simplicity and compliance.
KrosFlo® KR2i TFF System
Single-use fully integrated benchtop TFF system for research and process development (PD) ranging from 2mL - 15L. Compatible with hollow fiber and flat sheet filters, this system features a peristaltic feed pump with 13 automated process modes.
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KrosFlo® KMPi TFF System
Fully automate 100 ml - 500 L UF/DF processes using an unparalleled combination of hardware integration with peristaltic pump, configurability and automation through modular, plug-and-play hardware.
Automated tangential flow filtration for pilot scale 200L - 5000L
Trusted for gentle processing of shear sensitive biologics like lipid nanoparticles (LNPs) for pilot scale and manufacturing.
KrosFlo® KTF TFF Systems
The KrosFlo KTF are a series of highly configurable single-use TFF systems for multiple unit operations, applications, and filter types. With volumes spanning across 1 to 5000L, users enjoy the unrivaled flexibility of processing large and small batch sizes within the same platform.
Fully automated TFF systems for GMP manufacturing 35mL - 2000L
Ideal for mRNA and gene therapy production, KrosFlo® RS TFF are out most advanced series of fully automated TFF systems built for GMP manufacturing. Customization available upon request.
KrosFlo® RS TFF Systems
The KrosFlo® RS are a series of tangential flow filtration (TFF) systems engineered for an era of new modalities. These systems are single-use and cGMP compliant with features like end-to-end automation, minimal hold-up volumes, and effortless scalability. Support automated ultrafiltration and diafiltration (UF/DF) processes for batch volume ranges of 35mL to 2000L.
PAT-Driven Control with Real-Time Concentration Analytics
Introducing our groundbreaking Real-time Process Management (RPM™) line of TFF instruments, a cutting-edge solution designed to revolutionize process control in tangential flow filtration (TFF) systems. At the core of this innovation lies the integration of the CTech™ FlowVPX® in-line UV-Vis spectrophotometer into our KrosFlo® TFF Systems, providing users with unprecedented real-time insights and control over ultrafiltration/diafiltration (UF/DF) processes during downstream bioprocess development.
Real-time Process Management Solutions
Our Real-time Process Management (RPM™) Systems establish a new benchmark for real-time process control in downstream bioprocessing by integrating of the PATsmart™ FlowVPX® in-line UV-Vis spectrophotometer into the KrosFlo® TFF Systems. This innovative solution empowers users to achieve unparalleled control and optimization of UF/DF processes, driving efficiency, quality, and innovation in biomanufacturing.
Why choose KrosFlo® Tangential Flow Filtration systems?
Repligen is a leader in Tangential Flow Filtration technologies, offering systems that combine cutting-edge innovation, reliable performance, and flexible scalability. By choosing our TFF systems, you can optimize your bioprocesses to maximize yields and increase operational efficiency.
Read more on Tangential Flow Filtration: A Complete Guide for Bioprocessing Professionals.
