Upstream Filtration Products

Upstream filtration in bioprocessing involves identifying microorganisms, preparing media, and increasing cell density in seed train and production bioreactors, with the goal of growing cells that will produce a desired protein, viral vector or plasmid DNA.

Current needs include intensifying cell density of the seed train (N-1) and production bioreactors, and continuous manufacturing.

As the innovation leader, Repligen is redefining upstream bioprocessing filtration with breakthrough technologies such as XCell ATF® alternating tangential flow (ATF) filtration for perfusion and process intensification, and combined tangential flow depth filtration (TFDF) systems.

Repligen also provides hands-on process and implementation consultation from global Field Applications Specialists.

XCell® ATF Systems

Simplify and intensify upstream bioprocessing. The XCell® ATF System, in single-use or stainless steel format, delivers high cell retention. High impact upstream solutions include N-1 perfusion, high productivity harvest, long-term perfusion and seed train intensification.

KrosFlo® TFDF® Systems

Game-changing TFDF® (Tangential Flow Depth Filtration) technology that simplify and intensify upstream viral vector bioprocessing, ideal for AAV, lentivirus, oncolytic, retrovirus, adenovirus, exosomes, and cells on microcarriers. 

ProConnex® Flow Paths for Systems

Expertly designed plug-and-play flow path

ProConnex® Flow Paths for TFF and Chromatography processes are single-use and engineered for optimum performance, reproducibility and time savings. System specific flow paths provide speed and reliability. Configured flow paths prioritize process requirements and sterility. ​

Fluid Management

Repligen offers innovative, designed-for-purpose storage and transfer solutions for fluid management within and between unit operations. These include flow paths, tubing, valves and gaskets, bottles and containers, totes, carts and cleanroom process equipment.