Application Note: Enhance AAV Purification Performance with Optimal Hollow Fiber Membrane Selection

In gene therapy manufacturing, every minute and molecule counts. This application note compares the Repligen Spectrum^® 100 kD modified polyethersulfone (mPES) hollow fiber membranes to a leading competitor polysulfone (PS) membrane in a AAV9 tangential flow filtration (TFF) process. Discover how membrane selection directly impacts processing speed, product recovery, and operational efficiency – and why the Spectrum mPES technology offers a decisive advantage.

Key Takeaways

Up to 38% Faster Processing: mPES membranes reduced AAV9 UF/DF run time by nearly 38% compared to PS
3x Higher Water Permeability: Enables higher potential flux and more efficient filtration
>95% Product Recovery: Maintains viral yield, outperforming the ~65% recovery of PS membranes

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