Application Note: Enhance AAV Purification Performance with Optimal Hollow Fiber Membrane Selection

Cover image of Repligen application note comparing 100 kD mPES and competitor PS hollow fiber membranes for AAV filtration, shown with page curl effect. In gene therapy manufacturing, every minute and molecule counts. This application note compares the Repligen Spectrum^® 100 kD modified polyethersulfone (mPES) hollow fiber membranes to a leading competitor polysulfone (PS) membrane in a AAV9 tangential flow filtration (TFF) process. Discover how membrane selection directly impacts processing speed, product recovery, and operational efficiency – and why the Spectrum mPES technology offers a decisive advantage.

Key Takeaways

Up to 38% Faster Processing: mPES membranes reduced AAV9 UF/DF run time by nearly 38% compared to PS
3x Higher Water Permeability: Enables higher potential flux and more efficient filtration
>95% Product Recovery: Maintains viral yield, outperforming the ~65% recovery of PS membranes

First Name

Last Name

Company

Title

Country

City

State

Province

Zip

Would you like to speak with a technical specialist about Spectrum® Hollow Fiber Filters?

I agree to Repligen Terms of Use. Learn more about how we use and protect your information in our Privacy Policy.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.