Membrane Types

With a broad choice of single-use module configurations, hollow filter membranes from Repligen use advanced hydrophilic membrane filtration chemistry to provide higher flux rates for faster processing times, excellent selectivity for separation applications, and low protein binding for higher product yields than other membrane chemistries.

Membrane Fiber internal diameter MWCO and Pore Size # Module Configurations # Effective Lengths
mPESModified Polyethersulfone 0.50 mm 1kD, 3kD, 5kD, 10kD, 30kD, 50kD, 70kD, 100kD, 300kD, 500kD, 750kD 7 3
mPESModified Polyethersulfone 0.75 mm 0.65µm 7 3
mPESModified Polyethersulfone 1.00 mm 3kD, 5kD, 10kD 30kD, 50kD, 70kD, 100kD, 300kD, 500kD, 750kD 7 3
ME Mixed Cellulose Ester 0.63 mm 0.1µm, 0.2µm 7 3
ME Mixed Cellulose Ester 1.00 mm 0.2µm 7 3
PS Polysulfone 0.5 mm 10kD, 50kD, 500kD and 0.05µm 7 3
PES Polyethersulfone 0.5 mm 0.2µm 7 3
PES Polyethersulfone 1.0 mm 0.2µm 7 3

Membrane Applications

The following table shows typical use of membrane chemistries by application.

Applications Membrane selection mPES ME ME PES
Concentration and diafiltration (buffer exchange) of proteins, peptides, enzymes, recombinant proteins 1, 3, 5, 10, 30, 50, 70,100kD x x
Depyrogenation of water / buffers 3, 10kD x x
Coating, diafiltration, fractionation and/or dewatering of nanoparticles 70,100,300,500,750kD, 0.2µm x x
Concentration and diafiltration of albumin (nominal MW 67kd) 10kD x
Concentration and diafiltration of monoclonal antibodies (155kd) 30kD x
Concentration and diafiltration of envelope and non-envelope virus 50, 70, 100, 300, 500, 750kD, 0.05µm x x
Clarification of cell lysates, viral-expressed cultures to recover product in permeate 500, 750kD, 0.05, 0.1µm x x x
Concentration and washing of insect, bacterial and/or mammalian cells 750kD, 0.1, 0.2, 0.65µm x x
Continuous bioreactor perfusion of cell culture 30, 50, 70, 100, 300, 500, 750kD, 0.2, 0.65µm x x x
Concentration and diafiltration of single-stranded or double-stranded nucleic acids 1, 3, 5, 10, 30, 50, 70,100kD x
Washing latex, polystyrene and other diagnostic particles to remove un-reactives / unbound drug substance 500, 750kD, 0.05, 0.1, 0.2, 0.65µm x x x

Manufacturing Centers of Excellence

Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.

Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands,  Germany and Estonia.


Customer First.

Support is part of the Repligen DNA. Our goal is to provide exceptional customer experience, and to support the efficient and successful adoption and implementation of all Repligen products and services.

  • Field Application Support
  • Customer Service
  • Field Service Engineers

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Hollow Fiber Calculator

Easy-to-use online Hollow Fiber Filter tool for calculating critical process parameters like Flow Rate Per Fiber, Holdup Volume, Total Surface Area, and more.