Spectrum® Hollow Fiber Membranes

Fully encapsulated in single-use modules, the membranes used in the hollow fiber filter modules from Repligen are constructed using four chemistries that are anisotropic in structure to deliver high flux rates, excellent separation, and low protein binding for higher product yields.

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Membrane Types

With a broad choice of single-use module configurations, hollow filter membranes from Repligen use advanced hydrophilic membrane filtration chemistry to provide higher flux rates for faster processing times, excellent selectivity for separation applications, and low protein binding for higher product yields than other membrane chemistries.

	Membrane	Fiber internal diameter	MWCO and Pore Size	# Module Configurations	# Effective Lengths
mPES	Modified Polyethersulfone	0.50 mm	1kD, 3kD, 5kD, 10kD, 30kD, 50kD, 70kD, 100kD, 300kD, 500kD, 750kD	7	3
mPES	Modified Polyethersulfone	0.75 mm	0.65µm	7	3
mPES	Modified Polyethersulfone	1.00 mm	3kD, 5kD, 10kD 30kD, 50kD, 70kD, 100kD, 300kD, 500kD, 750kD	7	3
ME	Mixed Cellulose Ester	0.63 mm	0.1µm, 0.2µm	7	3
ME	Mixed Cellulose Ester	1.00 mm	0.2µm	7	3
PS	Polysulfone	0.5 mm	10kD, 50kD, 500kD and 0.05µm	7	3
PES	Polyethersulfone	0.5 mm	0.2µm	7	3
PES	Polyethersulfone	1.0 mm	0.2µm	7	3

Membrane Applications

The following table shows typical use of membrane chemistries by application.

Applications	Membrane selection	mPES	ME	ME	PES
Concentration and diafiltration (buffer exchange) of proteins, peptides, enzymes, recombinant proteins	1, 3, 5, 10, 30, 50, 70,100kD	x		x
Depyrogenation of water / buffers	3, 10kD	x		x
Coating, diafiltration, fractionation and/or dewatering of nanoparticles	70,100,300,500,750kD, 0.2µm	x		x
Concentration and diafiltration of albumin (nominal MW 67kd)	10kD	x
Concentration and diafiltration of monoclonal antibodies (155kd)	30kD	x
Concentration and diafiltration of envelope and non-envelope virus	50, 70, 100, 300, 500, 750kD, 0.05µm	x		x
Clarification of cell lysates, viral-expressed cultures to recover product in permeate	500, 750kD, 0.05, 0.1µm	x	x	x
Concentration and washing of insect, bacterial and/or mammalian cells	750kD, 0.1, 0.2, 0.65µm	x	x
Continuous bioreactor perfusion of cell culture	30, 50, 70, 100, 300, 500, 750kD, 0.2, 0.65µm	x		x	x
Concentration and diafiltration of single-stranded or double-stranded nucleic acids	1, 3, 5, 10, 30, 50, 70,100kD	x
Washing latex, polystyrene and other diagnostic particles to remove un-reactives / unbound drug substance	500, 750kD, 0.05, 0.1, 0.2, 0.65µm	x	x	x

RGEN

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Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.

Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands, Germany and Estonia.

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