Opinions are those of the authors and not of Repligen Corporation

Published 2018, 163 pages



Continuous Bioprocessing: Industry Best Practices

Continuous Bioprocessing: Industry Best Practices
February 2018
E-book: Volume 2

The opinions expressed in this book are those of the authors and not of Repligen Corporation.

  1. Introduction to Continuous Bioprocessing: Current Status and Trends

  2. How to Develop a Perfusion Process

  3. Strategies for Development of Perfusion Media

  4. Perfusion Application in Mobius® Single-Use Bioreactors

  5. XCell™ Perfusion Technology Delivers High Throughput: Efficent Seed Train Process with Improved Fed-Batch Production Output

  6. Product Quality Considerations of Perfusion Processes

  7. Impurity Monitoring as Novel PAT Tool for Continuous Biopharmaceutical Processes

  8. Insect cells and ATF

  9. Scale up and Technology Transfer in a Continuous Processing Environment

  10. Continuous Multicolumn Chromatography Processes

  11. Impact of Single-use Technology on Continuous Bioprocessing

  12. Continuous Bioprocessing's Impact on Facility Design


Continuous Bioprocessing: Current Practices and Future Potential
E-book: Volume 1

Download Volume 1

CaptivA® Resin | OPUS® Pre-packed Columns

Reducing Clinical-Phase Manufacturing Costs: Collaborating for Savings without Compromising Quality or Performance

by Dana Pentia et al.

BioProcess International 14(1)
December 2016


TangenX™ Tangential Flow Filtration Products

Impact of Single-Use Tangential Flow Filtration in Downstream Bioprocessing
May 2017

Spectrum® Hollow Fiber Filtration Systems

KrosFlo KR2i with KONDUiT: Turnkey Benchtop System for Walkaway TFF Automation
June 2018

Faster processing for biosimilars
by Coherus Biosciences
Tecan Journal
January 2017

Special Report on Continuous Bioprocessing: Upstream, Downstream, Ready for Prime Time?
by Angelo DePalma
BioProcessing International
May 11, 2016

Prepacked Chromatography Columns: Evaluation for Use in Pilot and Large-Scale Bioprocessing
by Shaun Grier and Saani Yakubu
BioProcess International
April 2016

WuXi Biologics Expands Perfusion Cell Culture Capabilities using ATF 10 System
In 2016, WuXi Biologics will add perfusion-based commerciall manufacturing services using the ATF 10 System coupled with 1,000 L single-use bioreactors.
Fall 2015

Quantitation of LONG®R3 IGF-I during production and purification of recombinant proteins from cell culture
by Thomas H. Ermak, Ph.D. and Amanda Flies, Ph.D.
Cell Sciences, Inc.
April 2015

Continuous Manufacturing: A Changing Processing Paradigm
By Randi Hernandez
BioPharm International, Volume 28, Issue 4
April  2015

A Novel Seed-Train Process: Using High Density Cell Banking, a Disposable Bioreactor, and Perfusion Technologies
By Benjamin Wright, Mike Bruninghaus, Mike Vrabel, Jason Walther, Neha Shah, Seul-A Bae, Timothy Johnson,Jin Yin, Weichang Zhou and Konstantin Konstantinov
BioProcess International
March 2015

Developing an upstream process for a monoclonal antibody including medium optimization
by Sevim Duvar, Volker Hecht, Juliane Finger, Matthias Gullans, Holger Ziehr
BioMed Central Ltd
June 2013

Shrinking the Costs of Bioprocess Development
by Gary Lye Jurgen Hubbuch Tim Schroeder Eric Willimann
BioProcess International
October 2009

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