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Dynamic Dialysis: A Novel Process-Scale Membrane Separation for GMP Manufacturing

Dynamic Dialysis: A Novel Method for Process Scale Membrane Separation

Daniel (Danny) Spurgin, Product Manager, Repligen

Cassidy Markee, Bioprocess Sales Specialist, Repligen

Abstract

While static dialysis is used routinely in research and sample analysis, dynamic dialysis is increasingly used today for the purification of macromolecules, proteins, nanoparticles, biomolecules, polymers (polypeptides, polysacharide, oligos), virus for vaccine and delicate/shear sensitive species. It is also ideal for the purification of viscous fluids and hydrogels (hyaluronic acid – HA) that cannot be filtered. Where traditional filtration methods may fail, dynamic dialysis uses flow dynamics to increase both the rate and efficiency of dialysis. In this webinar, we will explore dialysis basics, introduce dynamic dialysis for process scale separation, and demonstrate the benefits of dynamic dialysis for bioprocessing.

Speaker Bios

Daniel (Danny) Spurgin is Product Manager at Repligen. He holds a B.S. from Santa Clara University and a Master of Business and Science for the Keck Graduate Institute for Applied Life Sciences at the Claremont Colleges. He has 10 years of life sciences industry experience and has worked in management consulting, startups, and large corporations. Prior to joining Repligen as a Product Manager, he was both a Product Manager and a Marketing Manager at Phenomenex, a Danaher company focused on chromatography and separation sciences. Cassidy Markee is a Bioprocess Sales Specialist at Repligen. He has a B.S. in Molecular Biology from San Jose State University.  He has served in many roles over 22 years, including technical support, sales manager, marketing manager, product manager and director of the dialysis business at Spectrum Inc., prior to its 2017 acquisition by Repligen.  Particularly pertaining to dialysis, he supported customers globally, helped with application development/optimization and initiated the process dialysis technology.  Before his time at Spectrum, he worked at Lawrence Livermore National Laboratory doing cancer research in the Biology and Biotechnology Research Program.