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Designed for bench-scale resin screening, process development, and sample preparation, OPUS® MiniChrom® Columns are pre-packed with user-specified resin and supplied ready to use with any liquid chromatography system. Flexible column dimension configurations (internal diameters, bed heights, volumes) allow comparative evaluation of process parameters and the construction of customized resin libraries.
Currently platformed in various process development projects, as well as for resin sampling by various resin vendors, over 30,000 OPUS® MiniChrom® Columns have been in used in the industry since 2007. Individual laser labeling containing Part Number and Serial Number ensure traceability to the corresponding performance data.
Available formats
Internal |
Bed Height |
Column Volume | |||
cm | mm | cm | mm | mL | |
0.5 | 5.0 | 1.0 | 10.0 | 0.2 | |
0.5 | 5.0 | 2.5 | 25.0 | 0.5 | |
0.5 | 5.0 | 5.0 | 50.0 | 1.0 | |
0.8 | 8.0 | 2.0 | 20.0 | 1.0 | |
0.8 | 8.0 | 5.0 | 50.0 | 2.5 | |
0.8 | 8.0 | 10.0 | 100.0 | 5.0 | |
1.13 | 11.3 | 5.0 | 50.0 | 5.0 | |
1.13 | 11.3 | 10.0 | 100.0 | 10.0 |
Internal diameter x Bed Height (cm)
Pre-packed columns provided ready to use
Packed with any user-specified process resin; Compatible with any liquid chromatography system
Internal diameter, bed height, and column volume configurations enable customization to specific process development needs
Reliable performance from process resins batch to batch
Up to 10 ml volume and 3 diameters
Small configuration drives reduced material needs, and saves valuable resin samples while delivering similar performance to larger preparative or process columns
Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.
The development of a purification workflow for a specific molecule requires evaluation of the resin and the operating conditions for each chromatography step.
Using a scale-down chromatography column configuration drives efficiency and higher throughput. The performance of OPUS® MiniChrom® Columns is equivalent to the performance of larger columns, yielding reliable and predictive chromatography performance data. Using these smaller scale-down columns for process development saves valuable samples, cost, resources and time.
Results can be saved in a resin library of preferred resins.
The development and manufacture of a biotherapeutic requires significant analytical characterization of in-process intermediates. Non-purified samples require sample preparation before analysis can be executed. OPUS® MiniChrom® Columns enable one-step purification of multiple samples in parallel.
Use of OPUS® MiniChrom® Columns generates 8-400 mg of sample per run.
Column inner diameter |
5 mm |
8 mm |
11.3 mm | |||||
Packed bed height |
10 mm |
25 mm |
50 mm |
20 mm |
50 mm |
100 mm |
50 mm |
100 mm |
Column volume |
0.2 mL |
0.5 mL |
1.0 mL |
1.0 mL |
2.5 mL |
5.0 mL |
5.0 mL |
10.0 mL |
Inner cross-sectional area |
0.2 cm2 |
0.5 cm2 |
1.0 cm2 |
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Connectors |
Fingertight 1/16", female (10-32) |
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Column material |
Polypropylene |
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Chemical stability |
All commonly used aqueous buffers, pH 1 – 14, organic solvents*. |
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Column storage solution |
AIEC and CIEC Columns: 20 % ethanol + 150 mM sodium chloride |
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Recommended storage temperature |
AIEC, CIEC, HIC, SEC and MMC: +4°C to +30°C |
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Working temperature |
+4°C to +30°C |
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Maximum working pressure |
Up to 30 bar |
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Flow velocity |
16 – 1000 cm/h** |
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Labelling |
Laser-etched on every individual column body. Label contains:
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