Repligen was recognized as a critical supplier for COVID-19 vaccine development. The team at the Rancho Dominguez Center of Excellence played a vital role in the successful production of over 500 million COVID-19 vaccines for a major manufacturer. We are proud of the part we play in the effort to end the pandemic.
Repligen introduces novel affinity resin for the purification of the SARS CoV-2 Spike Protein for vaccine development and manufacturing. NGL COVID-19 Spike Protein Affinity Resin binds the SARS-CoV-2 Spike Protein receptor binding domain (RBD) to yield exceptional purity in a single chromatography step. The resin is available in off-the shelf, pre-packed and pre-qualified OPUS® Columns for rapid implementation as well as in loose resin formats.
Rapid response with COVID-19 prioritized lead times
Proven technologies with broad customer base from clinical to commercial = reduced risk
Adoption in diverse platforms including mAbs, proteins, viruses, plasmids, AAV, Lentivirus, mRNA
Expert-guided priority support for rapid technology implementation
Leading technologies for upstream process intensification, downstream processing, process analytics - scalable from bench to production scale
Closed, single-use bioprocessing — single-use, Gamma-irradiated, fully integrated flow paths
Configurable, sterile assemblies
Reduced installation time
High capacity rPA affinity resin
at a fraction of the cost
Configurable, sterile assemblies
Reduced installation time
Needs and Challenges
Downstream solutions
Needs and Challenges
Upstream solutions
Combines centrifugation and primary depth filtration, scalable from 1 to 2000L
Downstream solutions
Needs and Challenges
Upstream solutions
Combines centrifugation and primary depth filtration, scalable from 1 to 2000L
Downstream solutions
Upstream solutions
Combines centrifugation and primary depth filtration, scalable from 1 to 2000L
Downstream solutions
OPUS® Columns with Purolite Protein A Resin
High capacity rPA affinity resin at a fraction of the cost
Spectrum® Hollow Fiber TFF Filters
Low shear TFF,
1400 configurations
Closed, Gamma-irradiated, no cleaning validation