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Solutions for COVID-19 Therapeutics, Vaccines
and Diagnostics


Repligen is ready to partner to help fast-track the development and manufacturing of your COVID-19 therapeutics, vaccines and diagnostics, featuring NGL COVID-19 Spike Protein Affinity Resin for the purification of COVID-19 vaccines.

Use our COVID-19 Hotline for prioritized product availability or expert support.

 NGL COVID-19 SPIKE PROTEIN AFFINITY RESIN

FOR THE PURIFICATION OF COVID-19 VACCINEs

Repligen introduces novel affinity resin for the purification of the SARS CoV-2 Spike Protein for vaccine development and manufacturing. NGL COVID-19 Spike Protein Affinity Resin binds the SARS-CoV-2 Spike Protein receptor binding domain (RBD) to yield exceptional purity in a single chromatography step. The resin is available in off-the shelf, pre-packed and pre-qualified OPUS® Columns for rapid implementation as well as in loose resin formats.

about ngl COVID-19 Spike Protein affinity resin

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Repligen IS A technology leader in therapeutics production

Rapid response with COVID-19 prioritized lead times

Proven technologies with broad customer base from clinical to commercial = reduced risk

Adoption in diverse platforms including mAbs, proteins, viruses, plasmids, AAV, Lentivirus, mRNA

Providing high impact solutions with priority support

Expert-guided priority support for rapid technology implementation

Leading technologies for upstream process intensification, downstream processing, process analytics - scalable from bench to production scale

Closed, single-use bioprocessing — single-use, Gamma-irradiated, fully integrated flow paths 

Upstream Solutions

XCell ATF® Technology for N-1 and Perfusion 

Smaller cell culture footprint
Increased productivity
 

KrosFlo® TFDF® for
Clarification

High flux and throughput
No filter prep; Small footprint
 

ProConnex® Flow Paths for Install-and-Go TFF 

Configurable, sterile assemblies
Reduced installation time
 

200x more potent than insulin

 

Low shear TFF
1400 configurations
 

Faster time to result
No dilution quantitation
 

Downstream Solutions

OPUS® Pre-packed
Columns for Purification

No self-pack equipment or process

 

OPUS® 5-80R Columns
with Purolite Pro A Resin

High capacity rPA affinity resin
at a fraction of the cost
 

ProConnex® Flow Paths
for Install-and-Go TFF

Configurable, sterile assemblies 
Reduced installation time
 

Walkaway automation
1400 filter configurations
 

Closed, Gamma-irradiated
No cleaning validation
 

Faster time to result
No dilution quantitation
 

Time-saving, cost-lowering Solutions

Expand All

Needs and Challenges

  • Low shear filtration for pDNA and mRNA purification
  • Closed single-use systems, automated and standardized platforms
  • Demand for manufacturing can be significant so facility thoughput important

Downstream solutions

OPUS® Pre-packed Columns

Ready-to-use, no packing expertise needed

Spectrum® Hollow Fiber TFF Filters

Low shear TFF,
1400 configurations

SIUS® Gamma
TFF Cassettes

Closed, Gamma-irradiated, no cleaning validation

ProConnex®
Flow Paths

Configurable, sterile assemblies, reduced intallation time

KrosFlo®
TFF Systems

Fully automated, scalable from bench to production

SoloVPE®
Analytics

No dilution protein quantitation

Needs and Challenges

  • High demand biologic - productivity, efficiency, throughput and process economics need to be considered
  • Closed single-use, automated and standardized TFF platforms
  • Scalable chromatography and filtration solutions

Upstream solutions

XCell ATF®
Systems

Higher pre-transfection viable cell density and total capsid titer

LONG®R3 IGF-I Growth Factor

200x more potent than insulin

KrosFlo® TFDF® Systems

Combines centrifugation and primary depth filtration, scalable from 1 to 2000L

Downstream solutions

OPUS® Pre-packed Columns

Ready-to-use, no packing expertise needed

Spectrum® Hollow Fiber TFF Filters

Low shear TFF,
1400 configurations

SIUS® Gamma
TFF Cassettes

Closed, Gamma-irradiated, no cleaning validation

https://www.repligen.com/technologies/pro-connex-flowpaths

ProConnex®
Flow Paths

Configurable, sterile assemblies, reduced intallation time

KrosFlo®
TFF Systems

Fully automated, scalable from bench to production

SoloVPE®
Analytics

No dilution protein quantitation

Needs and Challenges

  • High demand biologic - productivity, efficiency, throughput and process economics need to be considered
  • Closed single-use, low shear, automated and standardized TFF platforms
  • Scalable chromatography and filtration solutions

Upstream solutions

Higher pre-transfection viable cell density and total capsid titer

200x more potent than insulin

KrosFlo® TFDF® Systems

Combines centrifugation and primary depth filtration, scalable from 1 to 2000L

Downstream solutions

Ready-to-use, no packing expertise needed

Low shear TFF,
1400 configurations

SIUS® Gamma
TFF Cassettes

Closed, Gamma-irradiated, no cleaning validation

ProConnex®
Flow Paths

Configurable, sterile assemblies, reduced intallation time

KrosFlo®
TFF Systems

Fully automated, scalable from bench to production

SoloVPE®
Analytics

No dilution protein quantitation

  • High demand biologic - productivity, efficiency, throughput and process economics need to be considered
  • Closed single-use, low shear, automated and standardized TFF platforms
  • Scalable chromatography and filtration solutions

Upstream solutions

XCell ATF®
Systems

Higher pre-transfection viable cell density and total capsid titer

LONG®R3 IGF-I Growth Factor

200x more potent than insulin

KrosFlo® TFDF® Systems

Combines centrifugation and primary depth filtration, scalable from 1 to 2000L

Downstream solutions

OPUS® Pre-packed Columns

Ready-to-use, no packing expertise needed

OPUS® Columns with Purolite Protein A Resin

High capacity rPA affinity resin at a fraction of the cost

Spectrum® Hollow Fiber TFF Filters

Low shear TFF,
1400 configurations

SIUS® Gamma
TFF Cassettes

Closed, Gamma-irradiated, no cleaning validation

ProConnex®
Flow Paths

Configurable, sterile assemblies, reduced intallation time

KrosFlo®
TFF Systems

Fully automated, scalable from bench to production

SoloVPE®
Analytics

No dilution protein quantitation

priority Support available remotely or in person

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