Designed for 100mL - 500L purification applications, the KrosFlo® KMPi TFF System from Repligen is designed for robust pilot-scale downstream ultrafiltration and microfiltration.
Fully integrated and ready to use out of the box, the KMPi provides consistent and accurate flow rates with a range of 0.01 to 13.0 LPM.
The fully integrated KrosFlo® KMPi TFF System consists of a digital peristaltic pump, multi-language interface with a graphical LCD display digital pressure monitor for automated alarm and shut-off controls, KMPi Pump head, scale for automated alarms and shut-off controls, Automatic Backpressure Valve, module stand, and proprietary KF Comm Software. The KrosFlo® KMPi provides consistent and accurate flow rates with a range of 0.01 to 13.0 LPM.
Includes filters, pumps, process monitors, software and graphic display
ProConnex® custom flow paths, 4 filter module configurations, 4 membrane chemistries, 2 effective filter lengths
Compatible with KrosFlo® TFF systems from process development to commercial manufacturing
Use with hollow fiber filters or flat sheet cassettes
KONDUiT add-on module for automated process control of conductivity, UV and temperature
Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.
Unique to Repligen, the KrosFlo® Back Pressure Control Valve is key to integrating and automating the TFF process, reducing operator process management time and TFF processing time.
Enhanced through an engineering design process, ProConnex® Flow Paths are customized, configurable and complete assemblies for tangential flow filtration. Designed for use with hollow fiber and/or flat sheet TFF systems, the assemblies are sterile, fit for upstream or downstream processing and manufactured in compliance with ISO guidelines in an ISO 7 clean room.
KF Comm 2 Software, backward compatible with legacy KrosFlo® KR2i and KrosFlo® KMPi Systems, is conveniently installed on any computer using the Windows Operating System. The software is comptaible with Chrome, Mozilla, Firefox and Microsoft Explorer browsers and is always current with automatic software and firmware updates.
| Primary Application |
Volume | Inlet/ Outlet | Side Port |
Scale Length |
Effective Length (cm) | Total Length (cm) |
Surface area |
|
|---|---|---|---|---|---|---|---|---|
MiniKros Sampler |
||||||||
 |
Batch TFF of small volumes | 3 L -15 L | 0.75" TC | 0.75" TC | 1 x FL 2 x FL 3 x FL |
20 41.5 65 |
25 47 70 |
490 – 1000 cm2 1000 - 2200 cm2 1600 - 3400 cm2 |
MiniKros |
||||||||
 |
Pilot-scale TFF | 5 L - 50 L | 1.5" TC | 0.75" TC | 1 x FL 2 x FL 3 x FL |
20 41.5 65 |
25 46 70 |
0.16 - 0.31 m2 0.32 - 0.65 m2 0.51 - 1.0 m2 |
KrosFlo® |
||||||||
 |
Production-scale TFF | 10 – 100L | 3" TC | 1.5" TC | 1 x FL 2 x FL 3 x FL |
20 41.5 65 |
23 46 69 |
0.78 - 1.6 m2 1.65 - 3.25 m2 2.55 - 5.10 m2 |
Monitor and evaluate conductivity, UV and temperature for automated process controls. KONDUiT is an add-on module ready to use with the KrosFlo® KR2i and KMPi TFF Systems, with the ability to scale from 2mL to 500L process volumes.
KONDUiT adds:
*UV components sold separately
| Conductivity Range | 0.1 to 100 mS/cm |
| Temperature Range | 0-70° |
| Pressure Range | up to 75 psi (5 bar) |
| Dimensions | (L x W x H): 7¾" x 4¾" x 4½" |
| Weight | 1.6 kg |
The KrosFlo® family of TFF Systems for ultrafiltration and diafiltration supports scale up from process development to commercial manufacturing.
KrosFlo® KR2i TFF System
2ml - 10L
KrosFlo® KMPi TFF System
1L - 500L
KrosFlo® KTF TFF System
500L - 5000L
Transducers
Scales
Maintain user-defined feed weight set-points, and total permeate mass during TFF processes.
Monitor
User-defined pressure alarms help ensure maximum sample recovery and membrane integrity.
KrosFlo® KR1 Auxiliary Pump
Auxiliary pumps automatically increase or decrease buffer/product addition to feed reservoir.
TangenX™ SIUS™ Flat Sheet Cassette Clamps
Stainless steel plates designed to be used with TangenX™ SIUS™ Cassettes and filter plate inserts.
