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TangenX™ Flat Sheet Cassettes

First-to-market with single-use TFF flat sheet cassettes, TangenX™ TFF technologies are reliable, scalable, and cost-effective solutions for efficient concentration and diafiltration.

How TFF works

TangenX™ SIUS™ Single-use TFF Cassettes

TangenX™ SIUS™ Cassettes are the first purpose-built single-use cassettes for tangential flow filtration (TFF). They deliver equivalent performace as reusable cassettes but with single-use convenience and at a fraction of the cost. 

  • 80% reduction in filter cost
  • 50% reduction in labor cost
  • 75% reduction in buffer cost
  • Scalable from lab to production
  • Interchangeable with TangenX™ PRO Reusable TFF Cassettes

TangenX™ SIUS™ Single-use TFF Cassettes

TangenX™ PRO Reusable TFF Cassettes

 

TangenX™ PRO Reusable Tangential Flow Filtration (TFF) Cassettes are flat sheet cassettes that may be cleaned and re-used multiple times while maintaining reproducible cassette performance. They are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up.

  • Equivalent performance, interchangeable with TangenX™ SIUS™ Single-use TFF Cassettes
  • Scalable from bench to production scale
  • Up to 30% filter cost reduction compared to other commercial reusable filters

TangenX™ PRO Reusable TFF Cassettes

Flat Sheet Membranes

Repligen manufactures two flat sheet TFF membranes: ProSteam™ and HySteam™. Both are modified Polyethersulfone (mPES) membranes validated for use in cGMP processes. Both ProSteam and HySteam membranes are available in TangenX™ SIUS™ Single-use Cassettes and TangenX™ PRO Reusable Cassettes.

  • No breakthrough of the ultrafiltration skin, which maximizes selectivity performance
  • Enhanced microporous substructure pore size and even transition, which maximize flux
  • Reduced number of manufacturing steps, which reduces cost and promotes excellent consistency and reliability

Flat sheet Membranes

TangenX™ Hardware

Designed to optimize tangential flow filtration, TangenX™ hardware include:

  • Cassette clamps
  • Cassette holders
  • Filter plate inserts
  • Low Holdup Volume (LHV) turnkey systems
  • Membrane screening systems

Tangenx™ hardware