TangenX™ Flat Sheet Cassettes

TangenX™ SIUS™ Single-use TFF Cassettes

TangenX™ SIUS™ Cassettes are the first purpose-built single-use cassettes for tangential flow filtration (TFF). They deliver equivalent performace as reusable cassettes but with single-use convenience and at a fraction of the cost. 

• 80% reduction in filter cost
• 50% reduction in labor cost
• 75% reduction in buffer cost
• Scalable from lab to production
• Interchangeable with TangenX™ PRO Reusable TFF Cassettes

TangenX™ SIUS™ Single-use TFF Cassettes

TangenX™ PRO Reusable TFF Cassettes

TangenX™ PRO Reusable Tangential Flow Filtration (TFF) Cassettes are flat sheet cassettes that may be cleaned and re-used multiple times while maintaining reproducible cassette performance. They are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up.

• Equivalent performance, interchangeable with TangenX™ SIUS™ Single-use TFF Cassettes
• Scalable from bench to production scale
• Up to 30% filter cost reduction compared to other commercial reusable filters

TangenX™ PRO Reusable TFF Cassettes

Flat Sheet Membranes

Repligen manufactures two flat sheet TFF membranes: ProStream™ and HyStream™. Both are modified Polyethersulfone (mPES) membranes validated for use in cGMP processes. Both ProStream and HyStream membranes are available in TangenX™ SIUS™ Single-use Cassettes and TangenX™ PRO Reusable Cassettes.

• No breakthrough of the ultrafiltration skin, which maximizes selectivity performance
• Enhanced microporous substructure pore size and even transition, which maximize flux
• Reduced number of manufacturing steps, which reduces cost and promotes excellent consistency and reliability

Flat sheet Membranes

TangenX™ Hardware

Designed to optimize tangential flow filtration, TangenX™ hardware include:

• Cassette clamps
• Cassette holders
• Filter plate inserts
• Low Holdup Volume (LHV) turnkey systems
• Membrane screening systems

Tangenx™ hardware