First-to-market with single-use TFF flat sheet cassettes, TangenX™ TFF technologies are reliable, scalable, and cost-effective solutions for efficient concentration and diafiltration.
TangenX™ SIUS™ Single-use TFF Cassettes
TangenX™ SIUS™ Cassettes are the first purpose-built single-use cassettes for tangential flow filtration (TFF). They deliver equivalent performace as reusable cassettes but with single-use convenience and at a fraction of the cost.
- 80% reduction in filter cost
- 50% reduction in labor cost
- 75% reduction in buffer cost
- Scalable from lab to production
- Interchangeable with TangenX™ PRO Reusable TFF Cassettes
TangenX™ PRO Reusable TFF Cassettes
TangenX™ PRO Reusable Tangential Flow Filtration (TFF) Cassettes are flat sheet cassettes that may be cleaned and re-used multiple times while maintaining reproducible cassette performance. They are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up.
- Equivalent performance, interchangeable with TangenX™ SIUS™ Single-use TFF Cassettes
- Scalable from bench to production scale
- Up to 30% filter cost reduction compared to other commercial reusable filters
Flat Sheet Membranes
Repligen manufactures two flat sheet TFF membranes: ProSteam™ and HySteam™. Both are modified Polyethersulfone (mPES) membranes validated for use in cGMP processes. Both ProSteam and HySteam membranes are available in TangenX™ SIUS™ Single-use Cassettes and TangenX™ PRO Reusable Cassettes.
- No breakthrough of the ultrafiltration skin, which maximizes selectivity performance
- Enhanced microporous substructure pore size and even transition, which maximize flux
- Reduced number of manufacturing steps, which reduces cost and promotes excellent consistency and reliability
TangenX™ Hardware
Designed to optimize tangential flow filtration, TangenX™ hardware include:
- Cassette clamps
- Cassette holders
- Filter plate inserts
- Low Holdup Volume (LHV) turnkey systems
- Membrane screening systems
