First-to-market with single-use TFF flat sheet cassettes, TangenX® TFF technologies are reliable, scalable, and cost-effective solutions for efficient concentration and diafiltration.
TangenX® SIUS® Single-use TFF Cassettes
TangenX® SIUS® Cassettes are the first purpose-built single-use cassettes for tangential flow filtration (TFF). They deliver equivalent performance as reusable cassettes but with single-use convenience and at a fraction of the cost.
- 80% reduction in filter cost
- 50% reduction in labor cost
- 75% reduction in buffer cost
- Scalable from lab to production
- Interchangeable with TangenX® PRO Reusable TFF Cassettes
TangenX® PRO Reusable TFF Cassettes
TangenX® PRO Reusable Tangential Flow Filtration (TFF) Cassettes are flat sheet cassettes that may be cleaned and re-used multiple times while maintaining reproducible cassette performance. They are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up.
- Equivalent performance, interchangeable with TangenX® SIUS® Single-use TFF Cassettes
- Scalable from bench to production scale
- Up to 30% filter cost reduction compared to other commercial reusable filters
TangenX® SIUS® Gamma Cassettes
TangenX® SIUS® Gamma TFF Devices embody the performance and efficiency of TangenX® SIUS® Cassettes in a convenient, fully assembled, closed, and irradiated system.
Simply clamp your TangenX® SIUS® Gamma TFF Device into a holder, connect to a flow path, and go. It's that easy.
Acclaimed performance with up to 30% flux increase over conventional membranes, connectivity freedom, and a library of configurations, converge into one, simple TFF solution.
Use TangenX® SIUS® Gamma TFF Devices for gene therapy applications, bioburden-sensitive operations, and hazardous processes.
Flat Sheet Membranes
Repligen manufactures two flat sheet TFF membranes: ProStream™ and HyStream™. Both are modified Polyethersulfone (mPES) membranes validated for use in cGMP processes. Both ProStream and HyStream membranes are available in TangenX® SIUS® Single-use Cassettes and TangenX® PRO Reusable Cassettes.
- No breakthrough of the ultrafiltration skin, which maximizes selectivity performance
- Enhanced microporous substructure pore size and even transition, which maximize flux
- Reduced number of manufacturing steps, which reduces cost and promotes excellent consistency and reliability
TangenX® Hardware
Designed to optimize tangential flow filtration, TangenX® hardware include:
- Cassette clamps
- Cassette holders
- Filter plate inserts
- Low Holdup Volume (LHV) turnkey systems
- Membrane screening systems
