TangenX® SIUS® Gamma filtration devices harness the performance and efficiencies of TangenX® SIUS® membranes and cassettes with the convenience of a fully assembled, closed and irradiated system.
PERFORMANCE TFF IN A CLOSED DEVICE WITH CONNECTION FREEDOM
TangenX® SIUS® Gamma filtration devices harness the performance and efficiencies of TangenX® SIUS® membranes and cassettes with the convenience of a fully assembled, closed and irradiated system.
Acclaimed performance with up to a 30% flux increase over conventional membranes, connectivity freedom and a library of molecular weight cutoffs, surface areas, chemistries and screen types converge into one, simple single-use flat-sheet solution. Manufactured under ISO 9001, every unit is integrity tested and quality tested.
Building closed systems can be challenging given the diversity of connectivity options available. TangenX® SIUS® Gamma Cassettes make your life easier by giving you connectivity choices. Either configure a ProConnex® flow path based on your specification, select a pre-built ProConnex® flow path that is ready-to-ship or simply plug the filtration device into your existing flow path with genderless AseptiQuik® connectors.
Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.
CLAMP AND GO. IT'S THAT EASY.
The TangenX® SIUS® Gamma device arrives as a fully assembled closed device, including cassette, manifold, clamps, tubing and genderless AseptiQuik® connectors. Simply clamp into a holder, make your flow path connections and run your process.
Components
- Hex nut
- Washer
- 3. 2" or 1" tie-rod spacer(s)
- Holder top plate
- TangenX™ SIUS™ Gamma Cassette
- Manifold
- Holder bottom plate
Configured for you
Build a specification based flow path from a library of over 400 components with individual quality
testing.
Plug into existing
Leverage the flexibility of genderless connectors and seamlessly connect to your existing flow path.
Ready to Ship
Order a pre-built and quality tested off-the shelf ProConnex® flow path stocked for rapid delivery.
FIT FOR GENE THERAPY
Ideal for AAV processes where large volumes need to be concentrated 20-60X prior to chromatography
QUALITY MANUFACTURING
Manufactured in compliance with ISO guidelines in an ISO 7 clean room
Defined lead times
GLOBAL SUPPORT
Work with Repligen Field Applications Specialists from consultation to implementation
Tangenx® Innovation Inside
- Same TangenX® SIUS® Flat Sheet Cassette membrane
- Single-cast membrane technology
- Selective pore sizes
- Clean flow path
- Efficient, precise cassette manufacturing
Diverse options for your diverse process needs
A wide selection of molecular weight cutoffs, surface areas, multiple chemistries and multiple screen types provide you with a library of options to address your diverse process requirements.
From sticky proteins to high concentration samples and from process development to manufacturing, the TangenX® SIUS® Gamma provides a closed solution. Scale, solve and move forward with one flat-sheet platform.
Membrane chemistries:
- ProStream® Membrane
- Neutrally balanced charge
- Low protein binding
- HyStream® Membrane
- Hydrophilic
- Low protein binding with minimal fouling with hydrophobic molecules
Screens:
Watch the webinar
TangenX® SIUS® Gamma TFF cassettes incorporate the performance-leading TangenX® TFF membrane and cassette manufacturing technologies into a closed, gamma-irradiated, single-use assembly. Genderless, aseptic connections easily integrate into your current UF/DF flow path, and a library of 64 MWCO and surface area configurations provide rich process options.
Equivalent performance with ready-to-use convenience
Seamless transition from TangenX® SIUS® Flat Sheet Cassette to TangenX® SIUS® Gamma Closed TFF Cassette
ProConnex® FLOW PATHS ADD FUNCTIONALITY AND CONVENIENCE
Custom ProConnex® Flow Paths complete your TFF solution
Custom
- Engineer-designed to customers’ specifications
- Choose from over 400 components
- connections
- process reservoirs
- pressure transducers
- aseptic connectors
Quality
- Individually inspected
- Integrity testing available
- Clean room assembled
- Double-bagged
Bioprocess Grade Materials
- Class VI
- BSE/TSE free
- Lot traceable
Clamp and go
- Complete flow path or drop-in tube sets
Validated Manufacturing
Quality Manufacturing
TangenX® Cassettes are manufactured in a fully validated and documented manufacturing process according to the principles of cGMP. Each cassette comes with a Quality Assurance Certificate.
Comprehensive Regulatory Support Files
Each TangenX® TFF Cassette is supported by a Regulatory Support File (available upon request) that includes:
- Product information
- Cassette design
- Materials of construction
- Product performance
- Safety information
- Documentation system
- Product Manufacturing
- Qualification
- Manufacturing Process Validation
- Release Testing
Resources
AAV Studies Deploying a Closed, Irradiated, Single-use Flat Sheet TFF Device
by David Bianchi, Carl Breuning, Michael LaBreck, Shelly Parra, Mary Jo Wojtusik, Repligen Corporation
Alex Meola, Michael Mercaldi, Thomas Thiers, Homology, Medicines Inc.
Repligen Corporation
Homology, Medicines Inc.
July 2020