TangenX® SIUS® Gamma TFF Devices embody the performance and efficiency of TangenX® SIUS® Cassettes in a convenient, fully assembled, closed, and sterile system.
Simply clamp your TangenX® SIUS® Gamma TFF Device into a holder, connect to a flow path, and go. It's that easy.
Acclaimed performance with up to 30% flux increase over conventional membranes, connectivity freedom, and a library of configurations, converge into one, simple TFF solution.
Use TangenX® SIUS® Gamma TFF Devices for gene therapy applications, bioburden-sensitive operations, and hazardous processes.
Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.
The diversity of connectivity options makes building closed systems a challenge. Genderless AseptiQuik® connectors featured on TangenX® SIUS® Gamma TFF Devices make life easier. Configure a ProConnex® Flow Path based on individual specifications, select a pre-built ProConnex® Flow Path that is ready-to-ship, or simply plug the filtration device into your existing flow path.
Simply clamp your TangenX® SIUS® Gamma TFF Device into a holder, connect to a flow path, and go. It's that easy.
Components
TangenX® SIUS® hardware can be purchased separately.
Build a specification based flow path from a library of over 250 components with individual quality
testing.
Order a pre-built and quality tested off-the shelf ProConnex® flow path stocked for rapid delivery.
Leverage the flexibility of genderless connectors and seamlessly connect to your existing flow path.
Custom Proconnex® Flow Paths complete your TFF solution
Custom
Quality
Bioprocess grade materials
Clamp and go
Transition from TangenX® SIUS® Cassettes to TangenX® SIUS® Gamma TFF Devices seamlessly.
Membrane performance is unaffected by exposure to gamma irradiation.
When comparing performance of TangenX® SIUS® Cassettes (solid line) and TangenX® SIUS® Gamma TFF Devices (dashed line):
TangenX® SIUS® Gamma TFF Devices are offered with two membrane chemistries, two screen types, a wide selection of molecular weight cutoffs (MWCO), and a broad range of surface areas. With 96 configurations available, TangenX® SIUS® Gamma TFF Devices accommodate diverse process requirements for ultrafiltration and diafiltration applications from process development to commercial manufacturing.
Membrane chemistries:
Screens:
TangenX® SIUS® Gamma TFF Devices are manufactured using a fully validated and documented manufacturing process according to the principles of cGMP. Each device comes with a Quality Assurance Certificate.
Each TangenX® SIUS® Gamma TFF Device is supported by a Regulatory Support File (available upon request) that includes:
AAV Studies Deploying a Closed, Irradiated, Single-use Flat Sheet TFF Device
by David Bianchi, Carl Breuning, Michael LaBreck, Shelly Parra, Mary Jo Wojtusik, Repligen Corporation
Alex Meola, Michael Mercaldi, Thomas Thiers, Homology, Medicines Inc.
Repligen Corporation
Homology, Medicines Inc.
July 2020