TangenX® SIUS® Gamma filtration devices harness the performance and efficiencies of TangenX® SIUS® membranes and cassettes with the convenience of a fully assembled, closed and irradiated system.
Acclaimed performance with up to a 30% flux increase over conventional membranes, connectivity freedom and a library of molecular weight cutoffs, surface areas, chemistries and screen types converge into one, simple single-use flat-sheet solution. Manufactured under ISO 9001, every unit is integrity tested and quality tested.
Building closed systems can be challenging given the diversity of connectivity options available. TangenX® SIUS® Gamma Cassettes make your life easier by giving you connectivity choices. Either configure a ProConnex® flow path based on your specification, select a pre-built ProConnex® flow path that is ready-to-ship or simply plug the filtration device into your existing flow path with genderless AseptiQuik® connectors.
Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.
The TangenX® SIUS® Gamma device arrives as a fully assembled closed device, including cassette, manifold, clamps, tubing and genderless AseptiQuik® connectors. Simply clamp into a holder, make your flow path connections and run your process.
Build a specification based flow path from a library of over 400 components with individual quality
Leverage the flexibility of genderless connectors and seamlessly connect to your existing flow path.
Order a pre-built and quality tested off-the shelf ProConnex® flow path stocked for rapid delivery.
Manufactured in compliance with ISO guidelines in an ISO 7 clean room
Defined lead times
Work with Repligen Field Applications Specialists from consultation to implementation
A wide selection of molecular weight cutoffs, surface areas, multiple chemistries and multiple screen types provide you with a library of options to address your diverse process requirements.
From sticky proteins to high concentration samples and from process development to manufacturing, the TangenX® SIUS® Gamma provides a closed solution. Scale, solve and move forward with one flat-sheet platform.
TangenX® SIUS® Gamma TFF cassettes incorporate the performance-leading TangenX® TFF membrane and cassette manufacturing technologies into a closed, gamma-irradiated, single-use assembly. Genderless, aseptic connections easily integrate into your current UF/DF flow path, and a library of 64 MWCO and surface area configurations provide rich process options.
Seamless transition from TangenX® SIUS® Flat Sheet Cassette to TangenX® SIUS® Gamma Closed TFF Cassette
Custom ProConnex® Flow Paths complete your TFF solution
Bioprocess Grade Materials
Clamp and go
TangenX® Cassettes are manufactured in a fully validated and documented manufacturing process according to the principles of cGMP. Each cassette comes with a Quality Assurance Certificate.
Each TangenX® TFF Cassette is supported by a Regulatory Support File (available upon request) that includes:
by David Bianchi, Carl Breuning, Michael LaBreck, Shelly Parra, Mary Jo Wojtusik, Repligen Corporation
Alex Meola, Michael Mercaldi, Thomas Thiers, Homology, Medicines Inc.
Homology, Medicines Inc.