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Where and When to Apply Upstream Process Intensification Technologies
Biopharmaceutical process intensification may be applied to multiple points in the workflow to increase productivity by orders of magnitude for diverse modalities, including recombinant proteins, vaccines, cell therapies, plasmid DNA and cultured meat. This webinar describes application of XCell ATF® Technology to the seed train and the production (N) bioreactor in different modes to create time, cost and facility efficiencies. 15+ years of published application data, implementation in the largest number of commercial processes and proven scaling from 1 L to 5000 L differentiate XCell ATF® Technology from all other upstream intensification methods. Considerations for when and why to apply XCell ATF® Technology in order to meet specific productivity goals will be discussed.
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Ready-to-use Dialysis Devices – Repligen
Only Repligen offers ready-to-use devices with ultrapure membrane to provide excellent sample recovery and ultimate convenience - no need for closures, knots, buoys, pontoons, or weights.
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Repligen Launches Single-Use XCell™ ATF System for Bioprocess Intensification
Complements Stainless Steel ATF Technology with Innovative Single-Use Format Improves Ease of Use for Biopharmaceutical Manufacturing Customers Offers Equivalent High Performance to Stainless Steel XCell™ ATF With Faster Implementation WALTHAM, Mass., Oct. 05, 2016 (GLOBE NEWSWIRE) - Repligen Corporation (NASDAQ:RGEN), a life sciences company focused on bioprocessing technology leadership, today announced the commercial launch of its single-use version of XCell™ ATF, a proprietary cell retention system used by biologic drug manufacturers to intensify cell culture and improve the efficiency and productivity of upstream processes. This innovative new single-use format, which will be offered alongside the existing stainless steel line, significantly reduces implementation time and improves overall ease of use for Repligen’s biopharmaceutical manufacturing customers. The new XCell ATF format aligns with single-use and continuous processing workflows that biomanufacturers are increasingly
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AAV case study: 3X titer with integrated clarification
Two case studies illustrate multi-fold upstream AAV titer increases for viral vector from HEK293 cells. In addition to productivity gains, XCell™ and TFDF® technologies clarify conditioned media for manufacturing operational simplicity. Product yield and process economics in the context of the current viral vector supply demand gap will be discussed.
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Key Milestones that Defined Modern Upstream Intensification Standards
Upstream bioprocess intensification has evolved over the past 20 years from an idea to a mature approach that has increased productivity by orders of magnitude and viable cell densities (VCD) in excess of 200 X 106 cell/mL. This webinar will walk through the key technical milestones achieved by the XCell ATF® technology over that span, providing a concise historical summary and definition of modern upstream intensification standards. Focus areas include controller and XCell ATF® advancements, transition to single-use, application extensions and key industry trends. While CHO cell lines expressing recombinant proteins remain the most common process, emerging applications include cultivated meat, cell therapies, animal vaccines, and plasmid DNA. Wholistic consideration of cell types, modalities, and scale-up from process development to manufacturing will provide context for the past, present and future of upstream intensification.
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Upstream Process Intensification for Virus Vaccine Manufacturing Case Study
Many viral manufacturing processes for animal health have been transferred from the time consuming and higher risk adherent culture systems to more scalable suspension cell cultures. Growing demand and the need for efficient and economic processes drive the continuous search for innovations. This talk describes studies conducted at MSD Animal Health to evaluate the XCell ATF® Technology for intensification of virus propagation on suspension cells.
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Investigation of XCell ATF® Perfusion Technology for virus manufacturing process intensification at MSD Animal Health White Paper
Repligen Corporation MSD Animal Health
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Sartorius and Repligen Corporation Launch Integrated System with Biostat STR® and XCell® ATF for Upstream Process Intensification
Bioreactor and cell retention technology integration features a single direct control interface to simplify intensified seed train implementation Customers experience optimized facility equipment installation, footprint, and maintenance requirements WALTHAM, Mass., Aug. 17, 2023 (GLOBE NEWSWIRE) - Sartorius and Repligen Corporation (NASDAQ:RGEN) today announced the launch of an integrated bioreactor system that incorporates Repligen XCell ® ATF upstream intensification technology into Sartorius’ Biostat STR ® bioreactor, simplifying intensified seed train and N perfusion implementation for biopharmaceutical manufacturers. The Biostat STR ® now contains a fully compatible embedded XCell ® ATF hardware and software module offering predefined advanced control recipes with integrated Process Analytical Technology (PAT). This system gives users a streamlined way to control cell growth and improve cell retention in perfusion processes without using a separate cell retention control tower.
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Disruptive technologies transforming upstream process intensification for all modalities
Opportunities to gain significant product yield and improve process efficiency exist today for nearly all modalities. Process intensification has been proven to lower cost of goods, increase productivity, reduce facility footprint, and increase throughput. This webinar highlights how the XCell ATF® and KrosFlo® TFDF® cell retention technologies are used to enable upstream process intensification. Industry case studies will be shown for multiple modalities including recombinant proteins, viral vectors and vaccines. Quantifiable improvements in yield, cost reduction and/or time are included.
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Hollow Fiber Filter Modules – Repligen
Hollow fiber filter modules for tangential flow filtration (TFF) from Repligen are industry standards in the filtration and concentration of biologics. Manufactured in compliance with ISO guidelines, the filters are used in thousands of Krosflo® TFF Systems and XCell™ ATF Systems worldwide, as well as other industry ho