Publications
Continuous Bioprocessing: Industry Best Practices
E-book Volume 2
February 2018
Compiled by John Bonham-Carter, Repligen
Chapters
- Introduction to Continuous Bioprocessing: Current Status and Trends
Eric S. Langer, BioPlan Associates, Inc. and and Ronald A. Rader - How to Develop a Perfusion Process
Véronique Chotteau, Royal Institute of Technology (KTH) - Strategies for development of perfusion media
Delia Lyons, MilliporeSigma and Jochen Sieck, Merck KGaA - Perfusion Application in Mobius® Single-use Bioreactors
Michael Cunningham and Douglas Rank, MIlliporeSigma - XCell ATF® Perfusion Technology Delivers High Throughput: Efficient Seed Train Process with Improved Fed-Batch Production Output
W. Roy Lin, Shashi Kudugunti, Mario Sinani, Tim Erlandson and Dr. James Rusche, Repligen - Product Quality Considerations of Perfusion Processes
Thomas Villiger, Daniel Karst and Massimo Morbidelli, ETH Zurich - Impurity Monitoring as Novel PAT Tool for Continuous Biopharmaceutical Processes
Vignesh Rajamanickam, Dr. Patrick Sagmeister, Oliver Spadiut, and Christoph Herwig, TU Wien Austria - Insect Cells and ATF
Willem Adriaan (Wian) de Jongh, PhD, ExpreS2ion Biotechnologies - Scale up and Technology Transfer in a Continuous Processing Environment
Sadettin S. Ozturk, Ph.D., Massbiologics - Continuous Multicolumn Chromatography Processes
Marc Bisschops, Pall Corporation - Impact of Single‑use Technology on Continuous Bioprocessing
William G. Whitford, GE Healthcare - Continuous Bioprocessing's Impact on Facility Design
Morten Munk, NNE A/S
Continuous Bioprocessing: Current Practice and Future Potential
E-book Volume 1
2014
Compiled by John Bonham-Carter, Repligen
Chapters
- Introduction to Continuous Manufacturing:Technology Landscape and Trends
Eric S. Langer and Ronald A. Rader, BioPlan Associates - A Brief History of Perfusion Biomanufacturing
Jerry Shevitz and John Bonham-Carter, Refine Technology - Bioreactor Configuration and Operation
Christel Fenge, Jörg Weyand, Gerhard Greller, Thorsten Adams, Sartorius Stedim Biotech - How to Develop a Perfusion Process
Véronique Chotteau, Royal Technical University, KTH - Case Study: Optimized Perfusion
Shaun Eckerle, Gallus BioPharmaceuticals - Process Intensification Approaches for Cost Sensitive Protein Applications
Willem Adriaan de Jongh, Expres2ion Biotechnologies - Impact of Single-use Technology on Continuous Biorocessing
William G. Whitford, Thermo Fisher Scientific - Continuous Multicolumn Chromatography Processes
Marc Bisschops, Tarpon Biosystems - Continuous Processes: Economic Evaluation
Andrew Sinclair and Andrew Brown, BioPharm Services - Vision: Integrating Upstream and Downstream in a Fully Continuous Facility
Tim Johnson, Genzyme
Technical and Application Notes
Data Sheets
Scientific Posters
Introducing 60 cm ID Pre-packed Chromatography Columns
Design Features of Pre-packed Disposables, Development to Production Scale
Performing Production Scale Chromatographic Separations in Pre-packed Disposable Columns
Implementing Disposable Chromatography: Technology Fit in Downstream Purification
45 cm ID OPUS® Pre-packed Disposable Chromatography Columns
Advancements in Large-scale Pre-packed Chromatography Columns
Automated Parallel Chromatographic Separations in Process Development
Innovative high throughput protein purification in 96-array format
High Productivity Harvest: A Novel Approach to Fed-batch Process Intensification
Mitigation of Protein Retention in Perfusion Process and Effect of Filter Pore Size
Demonstration of XCell ATF® 2 and XCell® ATF 6 Single-use Performance
Mitigation of Protein Retention in High Density Perfusion Process
Tools for Intensification of Cell Culture Production and Continuous Downstream Processing
ATF Perfusion Technology: Improved Fed-Batch Throughput and Reduced Seed Train Expansion
White Papers
Gene Therapy Manufacturing 2.0
by René Gantier, PhD, Director of Gene Therapy Technologies, Repligen Corporation
Repligen Corporation
April 2021
by Dana Pentia et al.
BioProcess International 14(1)
December 2016
AAV Studies Deploying a Closed, Irradiated, Single-use Flat Sheet TFF Device
by David Bianchi, Carl Breuning, Michael LaBreck, Shelly Parra, Mary Jo Wojtusik, Repligen Corporation
Alex Meola, Michael Mercaldi, Thomas Thiers, Homology, Medicines Inc.
Repligen Corporation
Homology, Medicines Inc.
July 2020
Repligen Corporation
MSD Animal Health
July 2022
Impact of N-1 Seed Train Intensification on Viral Vector Production
by Ly Truong, Riaj Mahamud, Benedict Kang, Keen Chung, Rene Gantier
Repligen Corporation
September 2022
Selected Third Party References
Production of Lentiviral Vectors Using a HEK-293 Producer Cell Line and Advanced Perfusion Processing
by Michelle Yen Tran and Amine A. Kamen
Frontiers, June 14, 2022
Lentiviral vector manufacturing process enchancement utilizing TFDF™ technology
by Thomas Williams, Oliver Goodyear, Lee Davies, Carol Knevelman, Michael Bransby, Kyriacos Mitrophanous and James Miskin
Cell and Gene Therapy Insights, April 2020
Special Report on Continuous Bioprocessing: Upstream, Downstream, Ready for Prime Time?
by Angelo DePalma
BioProcess International, May 2016
Continuous Manufacturing: A Changing Processing Paradigm
By Randi Hernandez
BioPharm International, Apr 01, 2015
A Novel Seed-Train Process: Using High-Density Cell Banking, a Disposable Bioreactor, and Perfusion Technologies
by Benjamin Wright, Mike Bruninghaus, Mike Vrabel, Jason Walther, Neha Shah, Seul-A Bae, Timothy Johnson, Jin Yin, Weichang Zhou and Konstantin Konstantinov
BioProcess International, March 2015
Developing an Integrated Continuous Bioprocessing Platform: Interview with Konstantin Konstantinov
by Maribel Rios
BioProcess International, December 2012
A Brief History of Perfusion Biomanufacturing: How High-Concentration Cultures Will Characterize the Factory of the Future
by John Bonham-Carter and Jerry Shevitz
BioProcess International, October 2011