Publications
Continuous Bioprocessing: Industry Best Practices
E-book Volume 2
February 2018
Compiled by John Bonham-Carter, Repligen
Chapters
- Introduction to Continuous Bioprocessing: Current Status and Trends
Eric S. Langer, BioPlan Associates, Inc. and and Ronald A. Rader - How to Develop a Perfusion Process
Véronique Chotteau, Royal Institute of Technology (KTH) - Strategies for development of perfusion media
Delia Lyons, MilliporeSigma and Jochen Sieck, Merck KGaA - Perfusion Application in Mobius® Single-use Bioreactors
Michael Cunningham and Douglas Rank, MIlliporeSigma - XCell™ Perfusion Technology Delivers High Throughput: Efficient Seed Train Process with Improved Fed-Batch Production Output
W. Roy Lin, Shashi Kudugunti, Mario Sinani, Tim Erlandson and Dr. James Rusche, Repligen - Product Quality Considerations of Perfusion Processes
Thomas Villiger, Daniel Karst and Massimo Morbidelli, ETH Zurich - Impurity Monitoring as Novel PAT Tool for Continuous Biopharmaceutical Processes
Vignesh Rajamanickam, Dr. Patrick Sagmeister, Oliver Spadiut, and Christoph Herwig, TU Wien Austria - Insect Cells and ATF
Willem Adriaan (Wian) de Jongh, PhD, ExpreS2ion Biotechnologies - Scale up and Technology Transfer in a Continuous Processing Environment
Sadettin S. Ozturk, Ph.D., Massbiologics - Continuous Multicolumn Chromatography Processes
Marc Bisschops, Pall Corporation - Impact of Single‑use Technology on Continuous Bioprocessing
William G. Whitford, GE Healthcare - Continuous Bioprocessing's Impact on Facility Design
Morten Munk, NNE A/S
Continuous Bioprocessing: Current Practice and Future Potential
E-book Volume 1
2014
Compiled by John Bonham-Carter, Repligen
Chapters
- Introduction to Continuous Manufacturing:Technology Landscape and Trends
Eric S. Langer and Ronald A. Rader, BioPlan Associates - A Brief History of Perfusion Biomanufacturing
Jerry Shevitz and John Bonham-Carter, Refine Technology - Bioreactor Configuration and Operation
Christel Fenge, Jörg Weyand, Gerhard Greller, Thorsten Adams, Sartorius Stedim Biotech - How to Develop a Perfusion Process
Véronique Chotteau, Royal Technical University, KTH - Case Study: Optimized Perfusion
Shaun Eckerle, Gallus BioPharmaceuticals - Process Intensification Approaches for Cost Sensitive Protein Applications
Willem Adriaan de Jongh, Expres2ion Biotechnologies - Impact of Single-use Technology on Continuous Biorocessing
William G. Whitford, Thermo Fisher Scientific - Continuous Multicolumn Chromatography Processes
Marc Bisschops, Tarpon Biosystems - Continuous Processes: Economic Evaluation
Andrew Sinclair and Andrew Brown, BioPharm Services - Vision: Integrating Upstream and Downstream in a Fully Continuous Facility
Tim Johnson, Genzyme
Technical and Application Notes
Scientific Posters
Introducing 60 cm ID Pre-packed Chromatography Columns
Design Features of Pre-packed Disposables, Development to Production Scale
Performing Production Scale Chromatographic Separations in Pre-packed Disposable Columns
Implementing Disposable Chromatography: Technology Fit in Downstream Purification
45 cm ID OPUS® Pre-packed Disposable Chromatography Columns
Advancements in Large-scale Pre-packed Chromatography Columns
Automated Parallel Chromatographic Separations in Process Development
Innovative high throughput protein purification in 96-array format
Mitigation of Protein Retention in Perfusion Process and Effect of Filter Pore Size
Demonstration of XCell™ ATF 2 and XCell™ ATF 6 Single-use Performance
Mitigation of Protein Retention in High Density Perfusion Process
Tools for Intensification of Cell Culture Production and Continuous Downstream Processing
ATF Perfusion Technology: Improved Fed-Batch Throughput and Reduced Seed Train Expansion
White Papers
by Dana Pentia et al.
BioProcess International 14(1)
December 2016
Selected Third Party References
Special Report on Continuous Bioprocessing: Upstream, Downstream, Ready for Prime Time?
by Angelo DePalma
BioProcess International, May 2016
Continuous Manufacturing: A Changing Processing Paradigm
By Randi Hernandez
BioPharm International, Apr 01, 2015
A Novel Seed-Train Process: Using High-Density Cell Banking, a Disposable Bioreactor, and Perfusion Technologies
by Benjamin Wright, Mike Bruninghaus, Mike Vrabel, Jason Walther, Neha Shah, Seul-A Bae, Timothy Johnson, Jin Yin, Weichang Zhou and Konstantin Konstantinov
BioProcess International, March 2015
Developing an Integrated Continuous Bioprocessing Platform: Interview with Konstantin Konstantinov
by Maribel Rios
BioProcess International, December 2012
A Brief History of Perfusion Biomanufacturing: How High-Concentration Cultures Will Characterize the Factory of the Future
by John Bonham-Carter and Jerry Shevitz
BioProcess International, October 2011