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KrosFlo RS TFF Systems

When Every drop counts

mRNA, AAV, Lentivirus developers

Need better automation

Efficiency and robustness seekers 

ready to scale fast  

Effortless transition across scales

Minimize hold-up volume with innovative valve block technology

Ideal for mRNA and gene therapy applications, KrosFlo® RS TFF Systems are engineered for maximum recovery.

The combination of injection molded tubing, over-molded connections, and valve blocks significantly lowers hold-up volume.

KrosFlo RS 20  Front - Circle_01SEP2022.png


how it works

Eliminate batch variation with end-to-end automation

Completely automate processes from start to finish without intervention.

Traditional single-use systems require manual manipulation due to the limited number of controlled valves. Additional controlled valves throughout the flowpath allow complete automation of processes.

Sanitization ​

  • WFI/Buffer Flushing​
  • Integrity testing


  • Fed-Batch Concentration​
  • Batch Concentration


  • Product Recovery  ​
  • Clean-in-place 

Maintain processes while scaling to production

Industrial grade components and extended automation allow for confident process scaling.

With the same software, hardware, controls and cGMP compliance built into every system, process change challenges in scale-up are removed.

KrosFlo® RS 20​

0.1 - 0.5 m²

KrosFlo® RS 30​

0.5 - 3 m² 

KrosFlo® RS 40​

1 – 5 m² 

KrosFlo® RS 50​

5 – 10 m² 

Intelligent mixing with the lowest working volume

Innovative tulip tank technology delivers hold-up volumes as low as 1.5L with active mixing.

As fluid levels drop, the dual impellers independently adjust speed to reduce harmful surface interaction while automated valves adapt retentate flow to avoid damage upon entering the tank.​

 KrosFlo RS 50 Front with Tulip - Circle_01SEP2022.png

Tulip Tank cart available with KrosFlo® RS 30, 40, 50

Error-free installation in minutes with preassembled flow kits

No confusing instructions or complicated assembly.

Pre-assembled flow paths are intuitively designed for simple, mistake-free installation. All system sensors come pre-calibrated and assembly is done in minutes.