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Macro Molecules

Applications in this therapeutic class include the bioprocessing of
       • Exosomes
​​​​​​​       • Nanoparticles
​​​​​​​       • Polysaccharides

Macro Molecule Process flow and Applications

 

Cell culture ►

 

Expansion of host cell
Cell line optimization
Cell banking
Media development
Seed train optimization
Cell Culture process development
Analytics

Applications
N-1 Perfusion
Media Exchange

Repligen solutions

 

Infection ► 

 

(if relevant)

 

Harvest ►

 

Centrifugation
Depth filtration (may be multi-stage)
Analytics

 

Purification ►

 

Resin screening
Capture / Polish chromatography
Scale-down validation
Tangential flow filtration
Analytics

Applications
Pre-packed column
UF/DF

Repligen solutions

 

Formulation

 

Filter screening
Tangential flow filtration
Analytics

Applications
Concentration and Diafiltration

Repligen solutions