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Running a Recipe
Running a fully automated cGMP process has never been easier. From recipe upload to completion, the software is here to make sure you stay on track.​
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pDNA
Plasmid DNA (pDNA) is a critical raw material delivery template for the development and production of mRNA or viral vectors such as lentivirus and adeno-associated virus (AAV) vectors.
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Drug-to-Antibody Ratio
Challenge: DAR is a critical quality attribute for ADCs, but offline methods are often low-throughput. Our Solution: FlowVPX enables in-line DAR monitoring for consistency and compliance during conjugation.
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Process Intensification
MORE. FASTER. Bioprocess intensification is defined as a significant step increase in output relative to cell concentration, time, reactor volume or cost, resulting in improvements in productivity, environmental and economic metrics.
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Peptide Mapping
Challenge: Sequence verification via traditional LC-MS peptide mapping is resource-intensive and slow. Our Solution: ZipChip enables rapid, high-resolution peptide mapping at-line to confirm sequence integrity and detect PTMs.
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DNA / RNA Quantification
Challenge: Measuring nucleic acid concentration post-encapsulation or purification is time-sensitive and prone to dilution error. Our Solution: SoloVPE PLUS delivers accurate, real-time quantification with no dilution, supporting both development and QC.
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Tulip tank case study: The unrecognized role of mixing during TFF
The degree of homogeneity in the feed that is delivered to the filters is a critical but often overlooked factor. Even small changes in the nature of the feed will drastically impact performance, resulting in deviations during diafiltration. This case study explores the impact of mixing dynamics on TFF performance. An innovative single-use Tulip Tank paired with the KrosFlo® RS 30 TFF system significantly improved performance as compared to traditional retentate vessels, reducing the gap between theoretical models and actual outcome.  
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High Productivity Harvest
High Productivity Harvest (HPH) is a novel application developed by Repligen that enables the harvest of a Fed-Batch bioreactor in a fully sterile manner ready for processing on a capture column, eliminating both centrifugation and depth filtration.
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Get in line: developing in-process analytical tools for gene therapy applications
Q&A Podcast and write-up for Biomanufacturing experts which include René Gantier, Director of Technology for Gene Therapy, Ramsey Shanbaky, Bioprocess Applications Manager, and Jay West, Principal Scientist at Bristol Myers Squibb. Authors: Ramsey, Rene, Jay West
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Repligen Launches TangenX® SC as First-to-Market Holder-Free Self-Contained TFF Device
Repligen Corporation yoday announced the commercial launch of TangenX® SC, the industry’s first holder-free, self-contained Tangential Flow Filtration (TFF) device.The technology is especially suited to the manufacture of biologics where fully closed systems are critical or ideal.
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