Viral Filtration Integrity: Validating the Gold Nanoparticle Test with the CTech™ SoloVPE® System White Paper
In this study, gold nanoparticles in downstream bioprocessing are determined utilizing the CTech™ SoloVPE® System with variable pathlength technology to perform the Slope Spectroscopy® method.
This paper demonstrates the suitability and utility of applying the SoloVPE System in place of traditional spectrophotometers for supporting in-process viral filtration integrity tests. With the passing of all predefined acceptance criteria, it is concluded that the SoloVPE instrument is capable of measuring the gold particle solution within specified accuracy, repeatability, specificity, and linearity.
Authors: Takeda-Ablatt Mahsut, Piyush Jain, Matt Diamond-Jones, Donald Gillies, and Nigel Herbert