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Search Results for "Alternating Tangential Flow Filtration関連"

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Go with the Flow: Evaluating the new CTech FlowVPX System for UF/DF-Protein Concentration
An evaluation of a beta version of the FlowVPX and Viper software was performed to determine it’s potential as an inline instrument for product concentration measurement during UF/DF operation, particularly high concentration UF/DF processes that are required for subcutaneous injection formulations ( greater than 150 g/L). The FlowVPX has significant potential for GMP and commercial biologics manufacturing unlike the first generation FlowVPE, which was designed as a lab scale instrument. Extensive testing was done using small and pilot scale UF/DF operations with several biologic drugs molecules from the portfolio. The FlowVPX instrument demonstrated very good comparability with other A280 based protein concentration measurements for all molecules tested (six). From a technical standpoint the FlowVPX is a GMP ready instrument, and further testing for instrument robustness and software development is ongoing at present to potentially use the instrument in the GMP space within the near future. Speaker: Jay West - BMS
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Go with the Flow: Protein concentration determination and automation during DP dilution processes using FlowVPE System
This presentation will give an overview of the journey from initial laboratory feasibility tests of the FlowVPE technology to implementation into an aseptic GMP facility for in-process control testing of biologics. In addition, the talk will highlight how the online technology sheds new light on the manufacturing process and increases product understanding. Building on the availability of real-time continuous protein concentration data, next steps in the development and implementation of a future automated human-free process execution will be shared. Speakers: Raf De Dier - Janssen
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Go with the Flow: Application of Variable Pathlength Technology for Rapid Determination of Dynamic Binding Capacity
An ever-increasing demand for biomolecule-based therapies is driving biopharmaceutical companies to accelerate process development activities to remain competitive in today’s industry. Within the downstream process development space, affinity chromatography is widely used for primary capture of monoclonal antibodies, Fc fusion proteins, etc. Optimization of this step requires determination of dynamic binding capacity (DBC) for target protein molecule and can be a lengthy process using traditional methods. KBI Biopharma has applied the use of variable pathlength technology for rapid generation of breakthrough curves and determination of DBC for capture resin selection.  Speaker: KBI Pharma-Rashmi Bhangale
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TangenX® PRO Cassettes
Repligen TangenX® PRO Reusable TFF Cassettes are interchangeable with SIUS Single-use TFF Cassettes, delivering equivalent performance, and scalability.
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Impact of Single-use Tangential Flow Filtration on Downstream Bioprocessing
Learn how SIUS™ Single-use Flat Sheet Cassettes can impact downstream productivity and process economics. May 7, 2017 | 20 minutes
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Go with the Flow: CTech FlowVPE System in combination with MALS for Real Time Molecular Weight (RT-MW) Applications
Multi Angle Light Scattering (MALS) can provide the real time molecular weight (Mw) of a pure solute or the average Mw of a solute matrix if the total concentration of the species is also available in real time. Analytical experiments with low protein concentration can use conventional fixed path length UV sensors, however these become saturated at the higher concentrations of manufacturing processes. The FlowVPE System enables the real time measurement of protein content in a wide concentration range, which can be coupled to MALS for RT-MW measurements. Besides a more agile process development, RT-MW can enable adaptive processing decisions and inform on product deviations Speaker: Andres Martinez-Roche
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Tutorial: Working with the KrosFlo® KR2i | Chapter 3: ProConnex Flow Paths
Learn how to combine the KrosFlo® KR2i TFF System with ProConnex® Flow Paths. December 2019 | 1 minute
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XCell ATF® Technology
XCell ATF® Technology achieves process intensification to deliver more product, faster. Intensified processes achieve higher cell densities, require smaller bioreactors and consume less suite time. Increase throughput, productivity, and capacity in both clinical and commercial manufacturing.
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Go with the Flow II: Implementing PAT strategy using the FlowVPX System for in-line monitoring during batch/continuous chromatography
As Seagen steps into next-gen processing, continuous processing has been one of our major area of focus for 2022. With the increasing production demands, process intensification requirements are increasing as well. To meet this, in-line process analytical technology (PAT) can enable comfortable processing. A stepping stone to this was our evaluation of VPX for further concentrating harvests and improving the chromatography efficiencies. Speaker: SeaGen-Aishwarya Ramanan
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PATsmart™ FlowVPX® System
Scalable In-line concentration measurement system for biologic process development and GMP manufacturing
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