Go with the Flow II: Biologics concentration measurement using the in-line FlowVPX instrument during the UF/DF process in drug substance manufacturing
The FlowVPX System was used as an in-line instrument for product concentration measurement during UF/DF operations, with orthogonal offline testing done to check comparability. The FlowVPX device has generated significant interest for high concentration UF/DF processes in particular (>150 g/L) since overconcentration can result in precipitation. The FlowVPX System has significant potential for GMP and commercial biologics manufacturing with the development of single use flow cells by the vendor.
Speaker: BMS-Jay West