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Minimize Risk With Rapid At-Line Concentration Measurement in Downstream Bioprocessing Applications (Webinar+Write Up)
In this webinar, we will review VPT and how it can be used in various applications from protein therapeutics to gene therapy. We will share real-world case studies demonstrating how companies have integrated the SoloVPE® System into their manufacturing workflow for release and in-process testing. Speaker: Paul Mania
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Fast Facts: Slope spectroscopy for gene therapy applications
Watch the video or read the poster to learn: Using slope spectroscopy – the powerful analytical method in which absorbance measurements are taken at various pathlengths using a variable pathlength spectrophotometer; Variable pathlength technology and how it compares to traditional fixed-pathlength UV-absorbance readings; How to implement the CTech™ SoloVPE® System for at-line in-process test (IPT) and as a process development tool. Speaker: Paul Mania
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Fast Facts: Accelerating downstream analytical testing for gene therapy
Watch the video or read the poster to learn:The benefits of rapid, reliable in-process testing for AAV downstream process development; How utilizing Slope Spectroscopy can remove or automate multiple process steps; Gene therapy case studies demonstrating use of the SoloVPE System to make real-time decisions for viral vector applications. Speaker: Harald Ehlen
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Viral vector manufacturing process - addressing bottlenecks with innovative solutions
In this webinar, we will share multiple applications and technologies that can address current manufacturing challenges and solutions to increase overall viral vector yield in various stages throughout the development and manufacturing processes. We will begin with strategies for intensifying plasmid DNA production, to secure the demand and quality of the raw material for AAV production. We will also discuss strategies to overcome the pain points associated with AAV and lentivirus production and purification at various manufacturing scales. 
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Case Study: Streamlining AAV titer determination using variable pathlength technology (Live Webinar & Article)
In this webinar, we will discuss a new method for AAV titer determination using real-time monitoring that eliminates the dependecy of off-line testing and associated variability caused by sample manipulation. We will demonstrate how at-line process controls, using variable pathlength technology, can offer quick and direct total viral vector analysis, during development to enhance throughput and improve decision-making. Speaker: PTC Therapeutics: Yan Chen (PTC)
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Streamlining At-Line and In-Line Concentration Measurements with the Variable Pathlength Technology Approach
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Fast Facts: Streamlining at-line and in-line concentration measurements with the Variable Pathlength Technology approach
Watch the video or read the poster to learn: What are the challenges of UV spectroscopy in pharmaceutical analysis? What is variable pathlength technology and how does it work? How can variable pathlength technology be used for at-line and in-line GMP applications? Speaker: Ramsey Shanbaky
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Optimizing E. Coli cell growth performance with in-line, real-time OD600 (abs/mm) monitoring during the fermentation process
This study proposes utilizing an inline- variable pathlength spectrophotometer in a recirculation loop during fermentation to monitor and optimize the growth of E. Coli cells in real-time. This provides distinct advantages vs traditional methods due to the constant modification of path lengths to create a slope-based solution that is always within the linear range of the equipment with no buffer correction required. The growth curve is tracked in real-time using the slope (Absorbance/mm) at 600nm to measure cell density and to optimize growth performance of E. Coli cells. This will serve as a proof-of-concept for the optimal cultivation of E. Coli and production of pDNA. Speakers: Tanja Buch, Ramsey Shanbaky
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