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Table
| Primary Application | Volume | Inlet/ Outlet | Side Port | Effective Length (cm) |
Total Length (cm) |
Surface Area | |
| MicroKros | |||||||
 Buy Now |
Process characterization, Small-volume TFF in a laboratory | 1-100 ml | MLL | FLL | 20
41.5 65 |
25 45 69 |
13 – 20 cm2
26 - 59 cm2 41 - 92 cm2 |
| MicroKros | |||||||
Buy Now |
Process characterization, Small-volume TFF in a laboratory | 1-100 ml | MLL | FLL | 20
41.5 65 |
25 45 69 |
13 – 20 cm2
26 - 59 cm2 41 - 92 cm2 |
| MicroKros | |||||||
Buy Now |
Process characterization, Small-volume TFF in a laboratory | 1-100 ml | MLL | FLL | 20
41.5 65 |
25 45 69 |
13 – 20 cm2
26 - 59 cm2 41 - 92 cm2 |
Secondary Hero
products
KrosFlo® KR2i TFF System
Single-use fully integrated benchtop TFF system for research and process development (PD) ranging from 2mL - 15L. Compatible with hollow fiber and flat sheet filters, this system features a peristaltic feed pump with 13 automated process modes.
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Modalities
A new generation of biologics
New modalities, such as viral vectors and mRNA, are critical in addressing challenging targets in bioprocessing. In addition to mAbs and rProteins, these exciting and potent clinical modalities promise faster, more efficient therapeutics with a broad range of potential applications.
Solutions for Viral Vector Bioprocessing
Adeno-associated virus (AAV) and Lentivirus (LV) are the most common viral vectors used in gene therapy bioprocessing. Other viral vectors include adenovirus, retrovirus, oncolytic virus, and virus-based vaccines.
Careers
Working at Repligen means being part of a team that is excited to find new and creative ways to overcome challenges
in bioprocessing — and to help our customers make a difference in the world.
Service Plans
Ensuring optimal performance, compliance, and reliability for your equipment.
Product Features
Product Features
Robust Processing
Ultrafiltration and diafiltration (UF/DF) processing for batch volumes ranging 2mL to 15L.
Easy to use
Plug and play configurability to add and remove components as needed with minimal effort.
Compatible with flat sheet cassettes and hollow fiber filters.
Walk-away automation
13 automated process control modes with the Automatic Back Pressure Valve (ABV) and intuitive software platform
Product Features
Robust Processing
Ultrafiltration and diafiltration (UF/DF) processing for batch volumes ranging 2mL to 15L.
Easy to use
Plug and play configurability to add and remove components as needed with minimal effort.
Compatible with flat sheet cassettes and hollow fiber filters.
Walk-away automation
13 automated process control modes with the Automatic Back Pressure Valve (ABV) and intuitive software platform.
Walk-away automation
13 automated process control modes with the Automatic Back Pressure Valve (ABV) and intuitive software platform.
Product Features
Robust Processing
Ultrafiltration and diafiltration (UF/DF) processing for batch volumes ranging 2mL to 15L.
Easy to use
Plug and play configurability to add and remove components as needed with minimal effort.
Compatible with flat sheet cassettes and hollow fiber filters.
Featured Object
TFF genius
You’re not asking for too much. Combine high selectivity and reduced processing time. Become a TFF genius and get it all with TangenX® Membranes and TFF Devices.
TFF genius
You’re not asking for too much. Combine high selectivity and reduced processing time. Become a TFF genius and get it all with TangenX® Membranes and TFF Devices.
Hotspot
Chromatography Redesigned
Repligen is revolutionizing how modern chromatography is performed. The result? Unprecedented recovery and operational efficiencies even with the most complex modalities.
Click on the image highlights to see key elements of chromatography redesigned.
Chromatography Redesigned
Repligen is revolutionizing how modern chromatography is performed. The result? Unprecedented recovery and operational efficiencies even with the most complex modalities.
Click on the image highlights to see key elements of chromatography redesigned.
Chromatography Redesigned
Repligen is revolutionizing how modern chromatography is performed. The result? Unprecedented recovery and operational efficiencies even with the most complex modalities.
Click on the image highlights to see key elements of chromatography redesigned.
Chromatography Redesigned
Repligen is revolutionizing how modern chromatography is performed. The result? Unprecedented recovery and operational efficiencies even with the most complex modalities.
Click on the image highlights to see key elements of chromatography redesigned.
Container
More Capabilities, StillSimple.
Get more out of TFF with the flexibility to configure your system to better suit your application needs. Keep your process compact and minimal or expand your capabilities to more advance modes of operation by adding components. Switch back and forth between configurations all without compromising on ease of use.
More Capabilities, StillSimple.
Get more out of TFF with the flexibility to configure your system to better suit your application needs. Keep your process compact and minimal or expand your capabilities to more advance modes of operation by adding components. Switch back and forth between configurations all without compromising on ease of use.
Text only
In addition to therapeutic proteins, new biological targets include gene therapy, viral vectors, mRNA, and whole cells. The new modalities rely on critical raw material delivery systems such as pDNA, and viral vectors such as AAV, adenovirus, lentivirus, retrovirus, exosomes, oncolytic virus, and virus-based vaccines. Emerging modalities focus on whole cell bioprocessing such as cultured meat, and therapies based on stem cells, cell therapy, and T cells.
Repligen solutions help overcome key challenges in the development and production of these modalities into a new class of drugs. Repligen also offers hands-on process and implementation consultation from global Field Applications Specialists, and recognized gene therapy, oncolytic and vaccines industry experts.
Product Resources
Resources
Tabbed Brick - WYSIWYG
Components and Accessories
- IP 33 Enclosure
- 600 RPM pump with reversible drive
- 90-260 Vrms @ 50/60 Hz
- Standard Easy Load 3 Pump Head for precision tubing L/S number 13, 14, 16, 25, 17, and 18 provided.
- (Optional) Easy Load 3 pump head for high performance tubing L/S numbers 15, 24, 35, 36
- ETL listed and CE/UL/cUL marked
- Pump Drive Dimensions: 10.5 in x 8 in x 8 in
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Bind with 2-minute residence time, Clear more HCP and DNA
Bind, wash and elute direct capture of AAV cell culture feed (not concentrated) stream using AVIPure® AAV2 Resin.
A 2 -minute residence time enabled elimination of an existing pre-concentration step. Product was eluted in 50 mM glycine, 150 mM NaCl, 0.01% P188, pH 3 with 85% recovery.
AVIPure® AAV2 Resin and a competing AAV affinity resin were run under identical conditions. The eluted product was analyzed for purity by SDS-PAGE, HCP and residual DNA.
Results
A 2 -minute residence time enabled elimination of an existing pre-concentration step. Product was eluted in 50 mM glycine, 150 mM NaCl, 0.01% P188, pH 3 with 85% recovery.
| Resin | Residual HCP | Residual DNA |
|---|---|---|
| AVIPure® AAV2 Resin | 4400 ppm | 4400 ppm |
| Supplier A | 33000 ppm | 33000 ppm |
AVIPure® AAV2 Resin and a competing AAV affinity resin were run under identical conditions. The eluted product was analyzed for purity by SDS-PAGE, HCP and residual DNA.
| Residual DNA |
Residual HCP
|
|---|---|
|
4400 ppm
|
AVIPure® AAV2 Resin
|
| Supplier A | 4400 ppm |
| 33000 ppm | 33000 ppm |
Components and Accessories
- IP 33 Enclosure
- 600 RPM pump with reversible drive
- 90-260 Vrms @ 50/60 Hz
- Standard Easy Load 3 Pump Head for precision tubing L/S number 13, 14, 16, 25, 17, and 18 provided.
- (Optional) Easy Load 3 pump head for high performance tubing L/S numbers 15, 24, 35, 36
- ETL listed and CE/UL/cUL marked
- Pump Drive Dimensions: 10.5 in x 8 in x 8 in
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.
Bind with 2-minute residence time, Clear more HCP and DNA
Bind, wash and elute direct capture of AAV cell culture feed (not concentrated) stream using AVIPure® AAV2 Resin.
A 2 -minute residence time enabled elimination of an existing pre-concentration step. Product was eluted in 50 mM glycine, 150 mM NaCl, 0.01% P188, pH 3 with 85% recovery.
AVIPure® AAV2 Resin and a competing AAV affinity resin were run under identical conditions. The eluted product was analyzed for purity by SDS-PAGE, HCP and residual DNA.
Results
A 2 -minute residence time enabled elimination of an existing pre-concentration step. Product was eluted in 50 mM glycine, 150 mM NaCl, 0.01% P188, pH 3 with 85% recovery.
| Resin | Residual HCP | Residual DNA |
|---|---|---|
| AVIPure® AAV2 Resin | 4400 ppm | 4400 ppm |
| Supplier A | 33000 ppm | 33000 ppm |
AVIPure® AAV2 Resin and a competing AAV affinity resin were run under identical conditions. The eluted product was analyzed for purity by SDS-PAGE, HCP and residual DNA.
| Residual DNA |
Residual HCP
|
|---|---|
|
4400 ppm
|
AVIPure® AAV2 Resin
|
| Supplier A | 4400 ppm |
| 33000 ppm | 33000 ppm |
Modal
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ProConnex® Flow Paths
Expertly designed plug-and-play flow path
ProConnex® Flow Paths for TFF and Chromatography processes are single-use and engineered for optimum performance, reproducibility and time savings. System specific flow paths provide speed and reliability. Configured flow paths prioritize process requirements and sterility.
ProConnex® TFDF® Flow Paths
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