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Chromatography Redesigned
Resin science breakthroughs and fluidics innovations have improved traditional process chromatography economics and efficiencies, especially in gene therapy and new modalities. Join us to discuss the technologies and applications that collectively transform legacy processes towards higher recovery, throughput and bioactivity. Learn from industry colleagues that adopted transformative technologies in an inspiring day of process advancements and data.
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Determination of bacterial growth curve using OD600 and the SoloVPE® Device
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Automating the UF/DF Process with In-Line Concentration Measurement to Reduce Cycling Time and Accelerate PD
This presentation will introduce an integrated system to automate the TFF process based on concentration measurement acquired via in-line variable pathlength spectroscopy. Real-time concentration measurement enables repeatable results, insensitive to the types of variation commonly seen in mass balance only systems. Automated process control is demonstrated for various final concentration endpoints, suggesting a better solution for the UF/DF process with key advantages over existing methods.
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Accelerating Plasmid Production by Optimizing Your Process Analytics
Plasmid DNA manufacturers that are looking for ways to accelerate production and confirm high quality product are encouraged to sign up for this webinar. We will share a platform process that will eliminate sample dilution and accurately measure DNA purity ratios in less than 5 minutes with an Rvalue accuracy of less than 2% deviation for all 25 sampling percentages. Slope spectroscopy has proven to be a critical analytical method, expediting the testing of challenging samples, providing immediate feedback, and opening up multiple possibilities for meeting your process needs. Speaker: Paul Mania
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Antibody Drug Conjugates
Antibody-drug conjugates (ADC) represent a breakthrough in targeted cancer therapy, combining the precision of monoclonal antibodies with the potency of cytotoxic drugs. By delivering powerful treatments directly to cancer cells, ADCs provide an alternative solution that enhances efficacy and minimizes side effects.
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Ultrafiltration Behavior of Partially Retained Proteins and Completely Retained Proteins Using Equally-Staged Single Pass Tangential Flow Filtration Membranes
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Multi-attribute PAT for UF/DF of Proteins—Monitoring Concentration, particle sizes, and Buffer Exchange
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Validating Protein Concentration of Antibody-Drug Conjugates with the CTech™ SoloVPE® System
 UV-Vis spectroscopy is the simplest and most common method to determine protein concentration of ADCs; however, traditional fixed-pathlength spectrophotometers have issues. Authors: Nigel Herbert, Joshua Das, Priya Patel-Abbvie
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Production of Lentiviral Vectors Using a HEK-293 Producer Cell Line and Advanced Perfusion Processing
By Michelle Yen Tran and Amine A. Kamen Frontiers
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Continuous Manufacturing: A Changing Processing Paradigm Publication
Although continuous manufacturing is well established for bulk chemicals, complex automation and validation challenges limit continuous applications for biologics manufacturing. While only a few approved biologic products in the market-less than 10%, according to estimates by Eric Langer, managing partner, BioPlan Associates-are manufactured through perfusion or continuous downstream processing, the field is evolving (1). Most of these processes are done piecewise, however, and are not truly continuous. 
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