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Repligen Corporation Announces Agreement to Acquire Bioprocess Systems Innovator ARTeSYN Biosolutions and Completes Acquisition of Non-Metallic Solutions
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Continuous Manufacturing
FROM BATCH TO CONTINUOUS Continuous manufacturing is a method for manufacturing pharmaceutical products from end-to-end on a single, uninterrupted production line. The aim is to eliminate batch inefficiencies that result in process stoppages, long hold times, and sub-optimal facility utilization.
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Evaluating DNA purity ratio determination with the CTech™ SoloVPE® System White Paper
Spectrophotometric analysis is one of the most common techniques used to quantitate nucleic acids in a solution. However, traditional fixed-pathlength spectrophotometers have limitations when determining the purity ratios of these molecules. In this study, the CTechTM SoloVPE system assessed theoretical DNA purity ratios by utilizing its variable pathlength method, known as Slope Spectroscopy. The method was evaluated by assessing the specificity, intermediate precision, repeatability, linearity, and accuracy of the theoretical purity ratios. The observed purity ratios from the SoloVPE system demonstrated great comparison to the theoretical purity ratios, verifying the SoloVPE system’s slope spectroscopy method to be preferable for this application. Authors: Nigel Herbert, Drusha Purohit, Hannah Mignault
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Viral Vectors
Adeno-associated virus (AAV) is the most common viral vector used in gene therapy bioprocessing. Other viral vectors include adenovirus, lentivirus, retrovirus, oncolytic virus, and virus-based vaccines.
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Viral Vector Manufacturing
Adeno-associated virus (AAV) is the most common viral vector used in gene therapy bioprocessing. Other viral vectors include adenovirus, retrovirus, exosomes, oncolytic virus, and virus-based vaccines.
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Running a Recipe
Running a fully automated cGMP process has never been easier. From recipe upload to completion, the software is here to make sure you stay on track.​
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pDNA
Plasmid DNA (pDNA) is a critical raw material delivery template for the development and production of mRNA or viral vectors such as lentivirus and adeno-associated virus (AAV) vectors.
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Drug-to-Antibody Ratio
Challenge: DAR is a critical quality attribute for ADCs, but offline methods are often low-throughput. Our Solution: FlowVPX enables in-line DAR monitoring for consistency and compliance during conjugation.
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Process Intensification
MORE. FASTER. Bioprocess intensification is defined as a significant step increase in output relative to cell concentration, time, reactor volume or cost, resulting in improvements in productivity, environmental and economic metrics.
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Peptide Mapping
Challenge: Sequence verification via traditional LC-MS peptide mapping is resource-intensive and slow. Our Solution: ZipChip enables rapid, high-resolution peptide mapping at-line to confirm sequence integrity and detect PTMs.
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