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DNA / RNA Quantification
Challenge: Measuring nucleic acid concentration post-encapsulation or purification is time-sensitive and prone to dilution error. Our Solution: SoloVPE PLUS delivers accurate, real-time quantification with no dilution, supporting both development and QC.
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Tulip tank case study: The unrecognized role of mixing during TFF
The degree of homogeneity in the feed that is delivered to the filters is a critical but often overlooked factor. Even small changes in the nature of the feed will drastically impact performance, resulting in deviations during diafiltration. This case study explores the impact of mixing dynamics on TFF performance. An innovative single-use Tulip Tank paired with the KrosFlo® RS 30 TFF system significantly improved performance as compared to traditional retentate vessels, reducing the gap between theoretical models and actual outcome.  
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High Productivity Harvest
High Productivity Harvest (HPH) is a novel application developed by Repligen that enables the harvest of a Fed-Batch bioreactor in a fully sterile manner ready for processing on a capture column, eliminating both centrifugation and depth filtration.
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Get in line: developing in-process analytical tools for gene therapy applications
Q&A Podcast and write-up for Biomanufacturing experts which include René Gantier, Director of Technology for Gene Therapy, Ramsey Shanbaky, Bioprocess Applications Manager, and Jay West, Principal Scientist at Bristol Myers Squibb. Authors: Ramsey, Rene, Jay West
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Repligen Launches TangenX® SC as First-to-Market Holder-Free Self-Contained TFF Device
Repligen Corporation yoday announced the commercial launch of TangenX® SC, the industry’s first holder-free, self-contained Tangential Flow Filtration (TFF) device.The technology is especially suited to the manufacture of biologics where fully closed systems are critical or ideal.
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Metabolomics
Challenge: Understanding cellular metabolism is essential, but metabolite shifts are transient and easily missed in offline workflows. Our Solution: With REBEL XT, real-time monitoring of nutrient consumption and byproduct accumulation drives smarter decisions on feed timing and culture viability.
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Advancing TFF for Small Scale CGMP Production with KrosFlo RS 10
The latest in TFF system innovation by Repligen is here Get an inside look into a new purpose-built single-use TFF system designed for process development and CGMP production of mRNA, gene therapies, and personalized medicine- The KrosFlo RS 10  While much of the equipment that is being leveraged for these applications today are repurposed from applications supporting significantly larger volume ranges, this system truly satisfies the demand for smaller scales. With unique features including complete end-to-end automation and optional real-time concentration measurement, this TFF system may be exactly what you need to produce your next blockbuster drug.
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Lentiviral vector manufacturing process enchancement utilizing TFDF™ technology
By Thomas Williams, Oliver Goodyear, Lee Davies, Carol Knevelman, Michael Bransby, Kyriacos Mitrophanous and James Miskin Cell and Gene Therapy Insights
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Continuous Bioprocessing: Current Practice And Future Potential Publication
E-book Volume 1 2014 Compiled by John Bonham-Carter, Repligen Chapters Introduction to Continuous Manufacturing:Technology Landscape and Trends Eric S. Langer and Ronald A. Rader, BioPlan Associates A Brief History of Perfusion Biomanufacturing Jerry Shevitz and John Bonham-Carter, Refine Technology Bioreactor Configuration and Operation Christel Fenge, Jörg Weyand, Gerhard Greller, Thorsten Adams, Sartorius Stedim Biotech How to Develop a Perfusion Process Véronique Chotteau, Royal Technical University, KTH Case Study: Optimized Perfusion Shaun Eckerle, Gallus BioPharmaceuticals Process Intensification Approaches for Cost Sensitive Protein Applications Willem Adriaan de Jongh, Expres2ion Biotechnologies Impact of Single-use Technology on Continuous Biorocessing William G. Whitford, Thermo Fisher Scientific Continuous Multicolumn Chromatography Processes Marc Bisschops, Tarpon Biosystems Continuous Processes: Economic Evaluation Andrew Sinclair and Andrew Brown, BioPharm Services Vision: Integrating Upstream and Downstream in a Fully Continuous Facility Tim Johnson, Genzyme
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Repligen acquires FlexBiosys Inc.
Repligen today entered an agreement to acquire FlexBiosys Inc. of Branchburg, NJ. The acquisition is another step in building out Repligen’s Fluid Management franchise, adding a full range of single-use bioprocessing bags and assemblies to our product offering. The addition of FlexBiosys complements and vertically integrates our systems offering, providing a more complete single-use fluid management portfolio of products for our biopharmaceutical manufacturing customers. Welcome FlexBiosys!  
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