Intensification starts here!
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KrosFlo® Tangential flow depth filtration (TFDF®) techology is used to overcome cell density and productivity challenges with virus production, manufacturing while streamlining the clarification process, offering a simplified alternative to batch cell culture methods.
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Simpler, Faster, Cheaper Advanced Therapy Manufacturing with Intensified Lentiviral Vector Production Using TFDF® -Based Perfusion Cell Culture
This study shows that KrosFlo® TFDF® perfusion technology increases active LV production by >10x from stable producer cells, enabling continuous harvesting while preserving functionality. For CAR-T therapy, a 10 L TFDF process can replace a 200 L batch system, reducing costs, footprint, and reagent use—accelerating commercialization.
Intensified AAV Production with TFDF®-based Perfusion Cell Culture
This article will examine the implementation of TFDF-based perfusion cell culture for viral vector production can limit the cell density effect, and, therefore, intensify the virus production compared to current batch processes.
Simplified Lentivirus and AAV clarification with TFDF®-based intensified virus production
In this paper we will look at how KrosFlo® TFDF® based process intensification leads to high virus production combined with simplified clarification compared to batch cell culture.